What is the NOAEL for 2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate?
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate has 4 NOAEL studies in the database. The lowest reported value is 6LE3UBK142 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate
Also known as: Propanoic acid, 2-methyl-, 2-methyl-4-oxo-4H-pyran-3-yl ester, EINECS 265-755-2, FEMA No. 3462, Maltyl 2-methylpropanoate, 2-Methyl-4-oxo-4H-pyran-3-yl 2-methylpropanoate (+4 more)
CAS 65416-14-0
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate (CAS 65416-14-0) is a chemical substance. Key regulatory status: 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS.
Cross-Vertical Regulatory Divergence
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
15 fields
Name
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate
CAS Number
65416-14-0
DTXSID
DTXSID4047703
Molecular Formula
C10H12O4
InChI Key
VSBHYRPUJHEOBE-UHFFFAOYSA-N
Monoisotopic Mass
196.073559
Synonyms
Propanoic acid, 2-methyl-, 2-methyl-4-oxo-4H-pyran-3-yl esterEINECS 265-755-2FEMA No. 3462Maltyl 2-methylpropanoate2-Methyl-4-oxo-4H-pyran-3-yl 2-methylpropanoate2-Methyl-4-pyron-3-yl 2-methylpropanoateUNII-6LE3UBK142Maltol isobutyrateMaltyl isobutyrate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
20 records
DeodorizerHumectantFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 6LE3UBK142 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LE3UBK142 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LE3UBK142 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6LE3UBK142 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3186742
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate?
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is 2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate used in cosmetics?
Yes, 2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate is also indexed as a cosmetic ingredient under the name Maltol Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate have different safety status in cosmetics vs industrial chemicals?
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate is prohibited in EU cosmetics but has active industrial GHS classifications (H317).
Is 2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate used outside industrial chemicals?
2-Methyl-4-oxo-4H-pyran-3-yl isobutyrate also appears in cosmetics, pharmaceutical, food safety, cannabis databases.