Good Cosmetic Ingredient NOAEL Data SCCS/CIR Reviewed

Laurtrimonium Bromide

Also known as: EINECS 214-290-3, UNII-6IC8NZ97S2, DDTMABr, DTAB, Dctab (+3 more)

INCI: LAURTRIMONIUM BROMIDE

Laurtrimonium Bromide (CAS 1119-94-4) is a cosmetic cosmetic ingredient functioning as Antistatic agent, surfactant–cleansing, hair conditioning. Reported NOAEL =10 mg/kg/d in mouse (CIR_vision_codex); EU Regulation 1223/2009 status: permitted; 3 safety opinions reviewed (cir). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 1119-94-4 →

Auto-generated CPSR Part A draft with source citations
Function
Antistatic agent, surfactant–cleansing, hair conditioning
Safety Rating
GOOD

Chemistry & Identifiers

Formula
C15H34BrN
MW
308.34 g/mol
EC Number
214-290-3
PubChem CID
14249
IUPAC Name
dodecyl(trimethyl)azanium bromide
InChIKey
XJWSAJYUBXQQDR-UHFFFAOYSA-M

Regulatory Status

EU EU Status permitted
US US Status permitted
US Notes Permitted — CIR reviewed in trimonium group assessment; safe in present practices of use

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Laurtrimonium Bromide.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

10 study endpoints found for Laurtrimonium Bromide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint Value Route Species Study Type Source
NOAEL =10 mg/kg/d dermal mouse NOAEL study CIR_vision_codex
NOAEL =10 mg/kg/d dermal mouse NOAEL study CIR_vision_codex
NOAEL =10 mg/kg/d dermal mouse NOAEL study CIR_vision_codex
NOAEL =10 mg/kg/d dermal mouse NOAEL study CIR_vision_codex
NOAEL =100 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =100 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =100 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =100 mg/kg oral rat oral toxicity CIR_vision_codex
NOAEL =500 mg/kg/d oral rat oral toxicity CIR_vision_codex
NOAEL =500 mg/kg/d oral rat oral toxicity CIR_vision_codex

Safety Opinions

Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).

cir
Verdict: unknown
NOAEL: 100 mg/kg (oral)
cir
Verdict: unknown
NOAEL: 10 mg/kg/d (dermal)
cir
Verdict: unknown
NOAEL: 10 mg/kg/d (oral)

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No

Function Categories & List Membership

Cosmetic/Chemical Function Categories
Anti-static agent Preservative Softener and conditioner

Expert Verdict

Expert safety assessment and concern-level summary for Laurtrimonium Bromide.

NOAEL Studies Summary

View details ->

Public NOAEL study rows linked to Laurtrimonium Bromide by CAS number or substance name.

Studies
12
Lowest NOAEL
10
Highest NOAEL
500

Units vary across source rows: mg/kg/d, mg/kg

CIR_vision_codex

Known Synonyms

EINECS 214-290-3 UNII-6IC8NZ97S2 DDTMABr DTAB Dctab LTAB N,N,N-Trimethyl-1-dodecanaminiuim bromide N-Lauryl-N,N,N-trimethylammonium bromide

Chemical Function

Preservative Anti-static agent Softener and conditioner

Regulatory Lists

active_ingredient; Europe; Pesticides

Australian Status

AICIS status: listed

Cross-Vertical Safety Context

Same-CAS public records found in pharmaceutical data.

SOURCE ChEMBL / DrugCentral / FAERS DB_PHARMA CAS match

Pharmaceutical Data

Same-CAS rows from the pharmaceutical spoke database.

ChEMBL ID
CHEMBL109873
View full pharmaceutical profile →

Frequently Asked Questions

Is Laurtrimonium Bromide safe in cosmetics?

Laurtrimonium Bromide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by cir.

Is Laurtrimonium Bromide allowed in the EU?

Laurtrimonium Bromide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.

What does Laurtrimonium Bromide do in cosmetics?

Laurtrimonium Bromide functions as: Antistatic agent, surfactant–cleansing, hair conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 1119-94-4.

What is the NOAEL for Laurtrimonium Bromide?

The NOAEL (No Observed Adverse Effect Level) for Laurtrimonium Bromide is =10 mg/kg/d based on a NOAEL study study via dermal route in mouse. A total of 10 study endpoints are available. Source: CIR_vision_codex.

Is Laurtrimonium Bromide used outside cosmetics?

Laurtrimonium Bromide also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.

Does Laurtrimonium Bromide have different safety status in cosmetics vs industrial chemicals?

Laurtrimonium Bromide is classified GHS Danger (H301, H302, H315, H317, H319, H335, H400, H410) in the chemicals database but is allowed in EU cosmetics.

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