Is LACTOBIONIC ACID safe in cosmetics?
LACTOBIONIC ACID has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
LACTOBIONIC ACID
Also known as: D-Gluconic acid, 4-O-β-D-galactopyranosyl-, 4-(β-D-Galactosido)-D-gluconic acid, 4-O-β-D-Galactopyranosyl-D-gluconic acid, 4-O-β-Galactopyranosyl-D-gluconic acid, D-Lactobionic acid (+7 more)
LACTOBIONIC ACID (CAS 96-82-2) is a cosmetic active ingredient functioning as Polyhydroxy acid (PHA) exfoliant with large molecular weight (358 Da) that. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 96-82-2 →
Auto-generated CPSR Part A draft with source citations
Function
Polyhydroxy acid (PHA) exfoliant with large molecular weight (358 Da) that confines exfoliating activity to the outermost stratum corneum layers. Provides gentle exfoliation without the burning or irritation associated with AHAs. Offers potent antioxidant activity and metal-chelating properties. Strong humectant effect from multiple hydroxyl groups. Suitable for rosacea-prone, post-procedure, and Fitzpatrick IV-VI skin types.
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR reviewed and assessed as safe in cosmetics. Polyhydroxy acid subclass distinct from AHA regulatory considerations. No photosensitivity concerns noted in clinical literature.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for LACTOBIONIC ACID.
Calculate MoS for your specific formulation with the MoS Calculator.
Dermal Penetration Profile
Skin absorption and penetration characteristics of LACTOBIONIC ACID, relevant to systemic exposure and MoS calculations.
Absorption %
1-3%
Penetration Level
surface
Penetration Depth
stratum corneum
Molecular Weight
358.3 Da
Log P
-3.8
Systemic Absorption
no
Topical Bioavailability
0.5-2%
Safety Margin Factor
minimal
Vehicle Dependent
Yes — absorption varies by formulation
Source: Cosmet Dermatol 2006
Additional Ingredient Properties
10 property records from structured ingredient metadata.
acne
{"cas_number": "96-82-2", "anti_acne_mechanism": "keratolytic/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "non_inflammatory", "p_acnes_mic_ug_per_ml": "No direct antibacterial", "sebum_reduction_pct_clinical": "5-8", "keratolytic_strength": "mild", "exfoliation_mechanism": "chemical", "optimal_ph_for_efficacy": "3.5-4.5", "peel_depth": "superficial", "prescriptio…
concentration
{"min_concentration_pct": "2.0", "max_concentration_pct": "10.0", "typical_concentration_pct": "5.0", "product_type": "Toner", "function_at_concentration": "Gentle PHA exfoliation, antioxidant", "source": "Supplier TDS"}
dermal_absorption
{"molecular_weight_da": "358.3", "log_p_value": "-3.8", "skin_penetration_level": "surface", "penetration_depth": "stratum corneum", "absorption_pct": "1-3", "systemic_absorption": "no", "penetration_enhancer": "no", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "strengthens", "bioavailability_topical_pct": "0.5-2", "safety_margin_factor": "minimal", "source": "Cosme…
exfoliant
{"cas_number": "96-82-2", "ingredient_class": "PHA", "chemical_subclass": "bionic_acid/aldobionic_acid", "molecular_weight_Da": "358.3", "pKa_value": "3.60", "pH_dependent_activity": "yes", "optimal_pH_range": "3.5-5.0", "penetration_depth": "stratum_corneum", "mechanism_of_action": "desmolysis", "target_bonds": "desmosomal", "onset_of_action": "hours", "peak_effect_timeline": "12-16 weeks", "cell…
ph_stability
{"optimal_ph_min": "4.0", "optimal_ph_max": "6.0", "stable_ph_min": "3.5", "stable_ph_max": "7.0", "degrades_above_ph": "8.0", "ph_dependent_function": "PHA, larger molecule", "formulation_note": "Gentler exfoliation with antioxidant properties", "source": "Formulation literature"}
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "not-rated", "reason": "PHA; large molecule, very gentle", "source": "dermatology literature"}
self_tanning
{"cas_number": "96-82-2", "ingredient_class": "tan_eraser", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_concern":…
skin_suitability
{"oily_skin": "recommended", "dry_skin": "recommended", "sensitive_skin": "recommended", "combination_skin": "recommended", "normal_skin": "recommended", "acne_prone": "acceptable", "rosacea": "recommended", "eczema": "recommended", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "recommended", "skin_benefit_primary": "exfoliating", "skin_benefit_secondary": "antiox…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for LACTOBIONIC ACID.
Regulatory Flags
pha
bionic-acid
antioxidant
chelating
no-photosensitivity
sensitive-skin-safe
barrier-safe
rosacea-safe
post-procedure-safe
fitzpatrick-iv-vi-preferred
Known Synonyms
D-Gluconic acid, 4-O-β-D-galactopyranosyl-
4-(β-D-Galactosido)-D-gluconic acid
4-O-β-D-Galactopyranosyl-D-gluconic acid
4-O-β-Galactopyranosyl-D-gluconic acid
D-Lactobionic acid
Galactosylgluconic acid
Lactonic acid
EC No.: 202-538-3
EINECS 202-538-3
UNII-65R938S4DV
4-(beta-D-Galactosido)-D-gluconic acid
202-538-3
Chemical Function
pH regulating agent
Regulatory Lists
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3039602
Frequently Asked Questions
Is LACTOBIONIC ACID allowed in the EU?
LACTOBIONIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does LACTOBIONIC ACID do in cosmetics?
LACTOBIONIC ACID functions as: Polyhydroxy acid (PHA) exfoliant with large molecular weight (358 Da) that confines exfoliating activity to the outermost stratum corneum layers. Provides gentle exfoliation without the burning or irritation associated with AHAs. Offers potent antioxidant activity and metal-chelating properties. Strong humectant effect from multiple hydroxyl groups. Suitable for rosacea-prone, post-procedure, and Fitzpatrick IV-VI skin types.. It is classified as a Active Ingredient in our database. CAS number: 96-82-2.
Is LACTOBIONIC ACID used outside cosmetics?
LACTOBIONIC ACID also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check LACTOBIONIC ACID compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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