Is L-Aspartic Acid safe in cosmetics?
L-Aspartic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 9 toxicological study endpoint(s) are available in our database.
L-Aspartic Acid
Also known as: (S)-2-Aminobutanedioic acid, L-Asparagic acid, L-2-Aminobutanedioic acid, Aminosuccinic acid, L-Asparaginsyra (+14 more)
INCI: ASPARTIC ACID
L-Aspartic Acid (CAS 56-84-8) is a cosmetic cosmetic ingredient functioning as Skin Conditioning (Humectant), Hair Conditioning, Buffering/pH Adjuster. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 56-84-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning (Humectant), Hair Conditioning, Buffering/pH Adjuster
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-aminobutanedioic acid
InChIKey
CKLJMWTZIZZHCS-REOHCLBHSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS per 21 CFR 172.320; no FDA cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for L-Aspartic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
9 study endpoints found for L-Aspartic Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | =452 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =463 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =491 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =497 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =500 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =697 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =715 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1200 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and respiratory tract.
Routes of Exposure
The substance can be absorbed into the body by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for L-Aspartic Acid across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =5000 mg/kg | Rabbit | dermal | - | ECHA IUCLID |
| LD50 | =5000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >16000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >5110 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =2000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =6000 mg/kg | Mouse | injection | - | ECHA IUCLID |
| LOAEL | =3049 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | =452 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =491 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =697 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
acne
{"cas_number": "56-84-8", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_ac…
anti_aging
{"anti_aging_claim": "hydration-plumping", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "5-10", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Int J Cosmet Sci", "improve…
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "no", "soluble_in": "water, glycerin, propylene glycol", "insoluble_in": "oils, ethanol, silicones", "log_p": "-3.5", "melting_point_c": "270", "appearance": "white powder", "source": "Ajinomoto"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1439
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Number
1429
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
L-ASPARTIC ACID | 2004 | No safety concern at current levels of intake when used as a flavouring agent | Not evaluated using the Procedure for the Safety Evaluation of Flavouring Agents; the substance is a macronutrient and a normal component of protein and, as such, human exposure through food is orders of magnitude higher than the anticipated level of exposure from use as a flavouring agent. | T
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
pH regulating agent
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for L-Aspartic Acid.
Regulatory Flags
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to L-Aspartic Acid by CAS number or substance name.
Studies
33
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
10000 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
(S)-2-Aminobutanedioic acid
L-Asparagic acid
L-2-Aminobutanedioic acid
Aminosuccinic acid
L-Asparaginsyra
Aspartate, L-
Aspatofort
BRN 1723530
EINECS 200-291-6
Acidum asparticum
L(+)-Aminobernsteinsaeure
L-Aspartinsaeure
Asparaginsaeure
UNII-30KYC7MIAI
(+)-Aspartate
(2S)-2-aminobutanedioic acid
(2S)-2-aminosuccinic acid
(2S)-Aspartate
(2S)-Aspartic acid
Chemical Function
pH regulating agent
Flavouring and nutrient
Regulatory Lists
pharmaceutical
pharmaceutical
Europe
Australia; Food and drug - smoking-related products
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ASPARTIC ACID
ChEMBL ID
CHEMBL274323
Max Phase
3
Adverse Event Associations
2
Frequently Asked Questions
Is L-Aspartic Acid allowed in the EU?
L-Aspartic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Aspartic Acid do in cosmetics?
L-Aspartic Acid functions as: Skin Conditioning (Humectant), Hair Conditioning, Buffering/pH Adjuster. It is classified as a cosmetic ingredient in our database. CAS number: 56-84-8.
What is the NOAEL for L-Aspartic Acid?
The NOAEL (No Observed Adverse Effect Level) for L-Aspartic Acid is 50 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 9 study endpoints are available. Source: COSMOS_DB.
Is L-Aspartic Acid used outside cosmetics?
L-Aspartic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check L-Aspartic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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