What is the NOAEL for L-Aspartic acid?
L-Aspartic acid has 24 NOAEL studies in the database. The lowest reported value is 206 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Aspartic acid
Also known as: (S)-2-Aminobutanedioic acid, L-Asparagic acid, aspartic acid, L-2-Aminobutanedioic acid, Aminosuccinic acid (+15 more)
CAS 56-84-8
L-Aspartic acid (CAS 56-84-8) is a chemical substance. Key regulatory status: REACH registered, 5 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
24
SOURCE
chemical inventory jurisdictions
Regulatory lists
5
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
L-Aspartic acid
CAS Number
56-84-8
DTXSID
DTXSID7022621
Molecular Formula
C4H7NO4
InChI Key
CKLJMWTZIZZHCS-REOHCLBHSA-N
Monoisotopic Mass
133.037508
Synonyms
(S)-2-Aminobutanedioic acidL-Asparagic acidaspartic acidL-2-Aminobutanedioic acidAminosuccinic acidL-AsparaginsyraAspartate, L-AspatofortBRN 1723530EINECS 200-291-6Acidum asparticumL(+)-Aminobernsteinsaeure
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and respiratory tract. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
pH regulating agentFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
5 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe | European Commission | Fl@vis |
| Australia; Food and drug - smoking-related products | New Zealand ESR | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =206 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 30KYC7MIAI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30KYC7MIAI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30KYC7MIAI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 30KYC7MIAI | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| >5110 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =3049 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 50 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| ~50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =452 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =463 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =491 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =497 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =500 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =697 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =700 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =700 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =700 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =715 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1100 | mg/kg bw/day | NOAEL | oral | rabbit | COSMOS_DB |
| =1200 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 1417 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Aspartic acid | 200-291-6 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
amino_acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ASPARTIC ACID
ChEMBL Phase
3
Adverse Events
2
Bioactivity
23
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Aspartic acid?
L-Aspartic acid appears on 4 regulatory/inventory lists including pharmaceutical, Europe, Australia; Food and drug - smoking-related products, and 1 more. Source: EPA CPDat.
Is L-Aspartic acid used in cosmetics?
Yes, L-Aspartic acid is also indexed as a cosmetic ingredient under the name L-Aspartic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Aspartic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Aspartic acid used outside industrial chemicals?
L-Aspartic acid also appears in cosmetics, pharmaceutical, cannabis databases.