Is L-Alanine safe in cosmetics?
L-Alanine has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
L-Alanine
Also known as: Alanine, L-, (2S)-2-Aminopropanoic acid, (S)-(+)-Alanine, (S)-2-Aminopropanoic acid, (S)-Alanine (+14 more)
INCI: ALANINE
L-Alanine (CAS 56-41-7) is a cosmetic cosmetic ingredient functioning as Skin Conditioning (Humectant), Hair Conditioning, Antistatic, Masking. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 56-41-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning (Humectant), Hair Conditioning, Antistatic, Masking
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-2-aminopropanoic acid
InChIKey
QNAYBMKLOCPYGJ-REOHCLBHSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS per 21 CFR 172.320; CIR concluded safe in present practices; USP purity ≥98-98.5%
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for L-Alanine.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
9 property records from structured ingredient metadata.
acne
{"cas_number": "56-41-7", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_ac…
anti_aging
{"anti_aging_claim": "hydration-plumping", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "4-8", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Int J Cosmet Sci", "improvem…
concentration
{"min_concentration_pct": "0.1", "max_concentration_pct": "2.0", "typical_concentration_pct": "1.0", "product_type": "Moisturizer", "function_at_concentration": "Skin conditioning", "source": "Clinical literature; Supplier TDS"}
hair_care
{"hair_function": "protein-treatment", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "all", "protein_sensitivity": "protein", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthen…
humectant
{"cas_number": "56-41-7", "ingredient_class": "humectant/NMF_component/amino_acid", "molecular_weight_Da": "89.09", "chemical_type": "amino_acid", "water_binding_mechanism": "hydrogen_bonding/hygroscopic", "water_holding_capacity_g_per_g": "0.3-0.5", "hygroscopicity_at_50_RH": "moderate", "hygroscopicity_at_80_RH": "good", "NMF_component": "yes", "NMF_percentage_natural": "1-2", "TEWL_reduction_pc…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "normal", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_children_products_eu": "no", "banned…
sensory
{"silky": "powdery", "smooth, glides easily": "smooth, conditioning", "dry-touch, non-greasy": "conditioned, soft", "instant": "fast", "low": "low", "w/o": "o/w", "very-high": "excellent", "no": "no", "yes": "no", "1.40": "1.42", "transparent": "opaque", "colorless": "white", "excellent": "excellent", "light": "light", "synthetic": "biotechnology"}
solubility_hlb
{"water_soluble": "yes", "oil_soluble": "no", "soluble_in": "water, glycerin, propylene glycol", "insoluble_in": "oils, ethanol, silicones", "log_p": "-2.8", "melting_point_c": "297", "appearance": "white powder", "source": "Ajinomoto"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for L-Alanine.
Regulatory Flags
fda_food_additive
Known Synonyms
Alanine, L-
(2S)-2-Aminopropanoic acid
(S)-(+)-Alanine
(S)-2-Aminopropanoic acid
(S)-Alanine
1561: PN: US20060223088 SEQID: 1571 claimed protein
2-Aminopropionic acid
L-(+)-Alanine
L-2-Aminopropanoic acid
L-2-Aminopropionic acid
L-α-Alanine
L-α-Aminopropionic acid
Lactamine
NSC 206315
Propanoic acid, 2-amino-, (S)-
α-Alanine
α-Aminopropionic acid
L-Alanin
L-alanina
Chemical Function
Flavouring and nutrient
Regulatory Lists
pharmaceutical
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ALANINE
ChEMBL ID
CHEMBL279597
Max Phase
3
Adverse Event Associations
2
Frequently Asked Questions
Is L-Alanine allowed in the EU?
L-Alanine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does L-Alanine do in cosmetics?
L-Alanine functions as: Skin Conditioning (Humectant), Hair Conditioning, Antistatic, Masking. It is classified as a cosmetic ingredient in our database. CAS number: 56-41-7.
Is L-Alanine used outside cosmetics?
L-Alanine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check L-Alanine compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Chemical family
Skin Conditioning Agent – Miscellaneous
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skin-conditioning agent - miscellaneous
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