What is the NOAEL for L-Alanine?
L-Alanine has 10 NOAEL studies in the database. The lowest reported value is 226.2 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Alanine
Also known as: Alanine, L-, (2S)-2-Aminopropanoic acid, (S)-(+)-Alanine, (S)-2-Aminopropanoic acid, (S)-Alanine (+14 more)
CAS 56-41-7
L-Alanine (CAS 56-41-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
L-Alanine
CAS Number
56-41-7
DTXSID
DTXSID20873899
Molecular Formula
C3H7NO2
InChI Key
QNAYBMKLOCPYGJ-REOHCLBHSA-N
Monoisotopic Mass
89.047678
Synonyms
Alanine, L-(2S)-2-Aminopropanoic acid(S)-(+)-Alanine(S)-2-Aminopropanoic acid(S)-Alanine1561: PN: US20060223088 SEQID: 1571 claimed protein2-Aminopropionic acidL-(+)-AlanineL-2-Aminopropanoic acidL-2-Aminopropionic acidL-α-AlanineL-α-Aminopropionic acid
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
Flavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =226.2 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| OF5P57N2ZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OF5P57N2ZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OF5P57N2ZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| OF5P57N2ZX | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =10 | mg/kg bw/day | LEL | injection | Cat | ToxValDB_ECHA_IUCLID |
| =30 | mg/kg bw/day | LEL | injection | Cat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | LEL | injection | Cat | ToxValDB_ECHA_IUCLID |
| 5000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 20000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | L-alanine | 200-273-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
amino_acid
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ALANINE
ChEMBL Phase
3
Adverse Events
2
Bioactivity
4
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
2 cannabis records found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Alanine?
L-Alanine appears on 3 regulatory/inventory lists including pharmaceutical, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is L-Alanine used in cosmetics?
Yes, L-Alanine is also indexed as a cosmetic ingredient under the name L-Alanine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Alanine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Alanine used outside industrial chemicals?
L-Alanine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.