INCI: ISOPROPYL CLOPROSTENATE
Isopropyl Cloprostenate (CAS 157283-66-4) is a cosmetic cosmetic ingredient functioning as Hair conditioning agent; eyelash/eyebrow growth stimulant; synthetic. Reported NOAEL =0.015 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: permitted; 1 safety opinion reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 157283-66-4 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Isopropyl Cloprostenate.
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8 study endpoints found for Isopropyl Cloprostenate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.015 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.015 mg/kg bw/d | dermal | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.1 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =0.1 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =0.1 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
| NOAEL | =0.1 mg/kg bw/day | oral | rat | reproductive toxicity | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
Expert safety assessment and concern-level summary for Isopropyl Cloprostenate.
Public NOAEL study rows linked to Isopropyl Cloprostenate by CAS number or substance name.
Units vary across source rows: mg/kg bw/d, mg/kg bw/day
Isopropyl Cloprostenate has a safety rating of "POOR" in our database. EU status: permitted. US status: restricted. 8 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Isopropyl Cloprostenate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Isopropyl Cloprostenate functions as: Hair conditioning agent; eyelash/eyebrow growth stimulant; synthetic prostaglandin F2α analog. It is classified as a cosmetic ingredient in our database. CAS number: 157283-66-4.
The NOAEL (No Observed Adverse Effect Level) for Isopropyl Cloprostenate is =0.015 mg/kg bw/d based on a dermal absorption study via dermal route in rat. A total of 8 study endpoints are available. Source: SCCS_vision_codex.
Isopropyl Cloprostenate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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