Is Isobutylthiazole safe in cosmetics?
Isobutylthiazole has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Isobutylthiazole
Also known as: 2-(2-Methylpropyl)thiazole, Thiazole, 2-(2-methylpropyl)-, EINECS 242-470-1, FEMA No. 3134, NSC 290430 (+2 more)
INCI: ISOBUTYLTHIAZOLE
Isobutylthiazole (CAS 18640-74-9) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 18640-74-9 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-(2-methylpropyl)-1,3-thiazole
InChIKey
CMPVUVUNJQERIT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Isobutylthiazole.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1034
Source: WHO/JECFA
JECFA Evaluation
2-ISOBUTYLTHIAZOLE | 2002 | No safety concern at current levels of intake when used as a flavouring agent | TRS 913-JECFA 59/65 | FAS 50-JECFA 59/265
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Isobutylthiazole.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
2-(2-Methylpropyl)thiazole
Thiazole, 2-(2-methylpropyl)-
EINECS 242-470-1
FEMA No. 3134
NSC 290430
Thiazole, 2-isobutyl-
UNII-7N03TDY75D
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1870000
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
2-ISOBUTYLTHIAZOLE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Isobutylthiazole allowed in the EU?
Isobutylthiazole EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Isobutylthiazole do in cosmetics?
Isobutylthiazole functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 18640-74-9.
Is Isobutylthiazole used outside cosmetics?
Isobutylthiazole also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Isobutylthiazole compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
ISOBORNYL DIPROPYLENE GLYCOL ETHERS
Good
Browse nearby
Antifoaming, Emulsion Stabilising, So...
ISOBUTYL METHACRYLATE/TRIFLUOROETHYLMETHACRYLATE/BIS-HYDROXYPROPYL DIMETHICONE ACRYLATE COPOLYMER
Good
Browse nearby
Film Forming, Hair Fixing
ISOBUTYLMETHACRYLATE/TRIFLUOROETHYLMETHACRYLATE/BIS-HYDROXYPROPYL DIMETHICONE ACRYLATE COPOLYMER
Good
Browse nearby
Film Forming, Hair Fixing, Skin Condi...
Is Isobutylthiazole in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Isobutylthiazole in your formulation.