Is Houttuynia Cordata Extract safe in cosmetics?
Houttuynia Cordata Extract has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
Houttuynia Cordata Extract
INCI: HOUTTUYNIA CORDATA EXTRACT
Houttuynia Cordata Extract (CAS 164288-50-0) is a cosmetic cosmetic ingredient functioning as Skin Conditioning - maintains the skin in good condition. Reported NOAEL =250 mg/kg/d in rat (CIR_vision_codex); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 164288-50-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning - maintains the skin in good condition
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not undergone formal regulatory safety assessment at EU or US level
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Houttuynia Cordata Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Houttuynia Cordata Extract. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =250 mg/kg/d | oral | rat | repeated dose toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
| NOAEL | =350 mg/kg/d | - | rat | developmental toxicity | CIR_vision_codex |
Additional Ingredient Properties
3 property records from structured ingredient metadata.
acne
{"anti_acne_mechanism": "antibacterial/anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "p_acnes_mic_ug_per_ml": ">500", "sebum_reduction_pct_clinical": "5-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "Yes (some…
anti_pollution
{"cas_number": "90131-61-8", "ingredient_class": "Nrf2_activator", "primary_mechanism": "enzyme_induction", "pollution_types_targeted": "PM2_5/PAH", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB…
depigmentation
{"cas_number": "not established", "ingredient_class": "combined_mechanism", "primary_mechanism_of_action": "Botanical extract with tyrosinase inhibition and/or antioxidant properties", "secondary_mechanisms": "Variable", "molecular_target": "other", "tyrosinase_inhibition_IC50_uM": "varies", "tyrosinase_inhibition_type": "competitive", "melanin_reduction_pct_in_vitro": "25-45", "melanin_reduction_…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Biocide
Deodorizer
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Houttuynia Cordata Extract.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Houttuynia Cordata Extract by CAS number or substance name.
Studies
8
Lowest NOAEL
250 mg/kg/d
Highest NOAEL
350 mg/kg/d
CIR_vision_codex
Chemical Function
Biocide
Antioxidant
Deodorizer
Softener and conditioner
Frequently Asked Questions
Is Houttuynia Cordata Extract allowed in the EU?
Houttuynia Cordata Extract EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Houttuynia Cordata Extract do in cosmetics?
Houttuynia Cordata Extract functions as: Skin Conditioning - maintains the skin in good condition. It is classified as a cosmetic ingredient in our database. CAS number: 164288-50-0.
What is the NOAEL for Houttuynia Cordata Extract?
The NOAEL (No Observed Adverse Effect Level) for Houttuynia Cordata Extract is =250 mg/kg/d based on a repeated dose toxicity study via oral route in rat. A total of 8 study endpoints are available. Source: CIR_vision_codex.
Compliance Tools
Check Houttuynia Cordata Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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