Is Hexyl Propionate safe in cosmetics?
Hexyl Propionate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Hexyl Propionate
INCI: HEXYL PROPIONATE
Hexyl Propionate (CAS 2445-76-3) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. Reported NOAEL =15 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 2445-76-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexyl propanoate
InChIKey
GOKKOFHHJFGZHW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS #2576; FDA-compliant; no 21 CFR 700 restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexyl Propionate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Hexyl Propionate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =15 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 8100 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
144
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEXYL PROPIONATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/297
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Hexyl Propionate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Hexyl Propionate by CAS number or substance name.
Studies
1
Lowest NOAEL
15 mg/kg bw/day
Highest NOAEL
15 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hexyl Propionate allowed in the EU?
Hexyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexyl Propionate do in cosmetics?
Hexyl Propionate functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 2445-76-3.
What is the NOAEL for Hexyl Propionate?
The NOAEL (No Observed Adverse Effect Level) for Hexyl Propionate is =15 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. Source: ToxValDB_ECHA_IUCLID.
Compliance Tools
Check Hexyl Propionate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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