What is the NOAEL for Hexyl propanoate?
Hexyl propanoate has 10 NOAEL studies in the database. The lowest reported value is 8R2W3UA8JV UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Hexyl propanoate
Also known as: BRN 1752269, EINECS 219-495-1, FEMA No. 2576, 1-Hexyl propanoate, UNII-8R2W3UA8JV (+7 more)
CAS 2445-76-3
Hexyl propanoate (CAS 2445-76-3) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Hexyl propanoate
CAS Number
2445-76-3
DTXSID
DTXSID5047582
Molecular Formula
C9H18O2
InChI Key
GOKKOFHHJFGZHW-UHFFFAOYSA-N
Monoisotopic Mass
158.13068
Synonyms
BRN 1752269EINECS 219-495-1FEMA No. 25761-Hexyl propanoateUNII-8R2W3UA8JV1-Hexyl propionateFEMA 2576N-Hexyl N-propionateN-Hexyl propionatePropanoic acid, hexyl esterPropionic acid, hexyl esterhexyl propionate
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
20 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8R2W3UA8JV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8R2W3UA8JV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8R2W3UA8JV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8R2W3UA8JV | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 8100 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >5000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =15 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| >=75 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Hexyl propionate | 219-495-1 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3186132
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Frequently Asked Questions
What regulatory lists include Hexyl propanoate?
Hexyl propanoate appears on 4 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 1 more. Source: EPA CPDat.
Is Hexyl propanoate used in cosmetics?
Yes, Hexyl propanoate is also indexed as a cosmetic ingredient under the name Hexyl Propionate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hexyl propanoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is Hexyl propanoate used outside industrial chemicals?
Hexyl propanoate also appears in cosmetics, pharmaceutical, food safety databases.