Is Hexapeptide-2 safe in cosmetics?
Hexapeptide-2 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Hexapeptide-2
Also known as: L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-, Histidyl-tryptophyl-alanyl-tryptophyl-phenylalanyl-lysinamide, Ghrp-6
INCI: HEXAPEPTIDE-2
Hexapeptide-2 (CAS 87616-84-0) is a cosmetic cosmetic ingredient functioning as Skin bleaching agent, skin conditioning agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 87616-84-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin bleaching agent, skin conditioning agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S)-6-amino-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-(1H-imidazol-5-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]hexanamide
InChIKey
WZHKXNSOCOQYQX-FUAFALNISA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR safety assessment exists for Hexapeptide-2. Falls under standard MoCRA compliance. No FDA GRAS classification applicable.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexapeptide-2.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "brightening, dark-spot-reduction", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, Int…
self_tanning
{"cas_number": "proprietary", "ingredient_class": "tan_accelerator", "tanning_mechanism": "melanin_stimulation", "color_development_onset_hours": "72.0", "full_color_development_hours": "240", "color_duration_days": "14", "color_depth": "light", "undertone": "natural", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_releas…
synergy
{"inci_name_2": "Niacinamide", "synergy_type": "efficacy-boost", "synergy_description": "Melanin-inhibiting peptide with melanosome blocker for brightening", "combined_benefit": "Enhanced skin brightening, dual-mechanism melanin control", "efficacy_multiplier": "2.2x", "mechanism_of_action": "Hexapeptide-2 inhibits melanin synthesis; niacinamide blocks melanosome transfer", "optimal_ratio": "1:10 …
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Hexapeptide-2.
Regulatory Flags
no-sccs-opinion
no-cir-monograph
no-dermal-absorption-data
no-sensitization-study
no-mos-calculated
skin-bleaching-agent
active-biological-function
Known Synonyms
L-Lysinamide, L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-
Histidyl-tryptophyl-alanyl-tryptophyl-phenylalanyl-lysinamide
Ghrp-6
Chemical Function
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL105462
Frequently Asked Questions
Is Hexapeptide-2 allowed in the EU?
Hexapeptide-2 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexapeptide-2 do in cosmetics?
Hexapeptide-2 functions as: Skin bleaching agent, skin conditioning agent. It is classified as a cosmetic ingredient in our database. CAS number: 87616-84-0.
Is Hexapeptide-2 used outside cosmetics?
Hexapeptide-2 also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hexapeptide-2 compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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