Is Hexadienyl Isobutyrate safe in cosmetics?
Hexadienyl Isobutyrate has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hexadienyl Isobutyrate
Also known as: Propanoic acid, 2-methyl-, 2,4-hexadien-1-yl ester, EINECS 240-551-6, 3,5-Hexadienyl isobutyrate, 2,4-Hexadienyl 2-methylpropanoate, Isobutyric acid, 2,4-hexadienyl ester (+3 more)
INCI: 2,4-HEXADIENYL ISOBUTYRATE
Hexadienyl Isobutyrate (CAS 16491-24-0) is a cosmetic cosmetic ingredient functioning as Fragrance. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 16491-24-0 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
hexa-2,4-dienyl 2-methylpropanoate
InChIKey
CVYBRMSQMLJGOI-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hexadienyl Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1782
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2,4-HEXADIENYL ISOBUTYRATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
SORBYL ISOBUTYRATE | 2007 | No safety concern at current levels of intake when used as a flavouring agent | TRS 947-JECFA68/ | FAS 59-JECFA68/
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Hexadienyl Isobutyrate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
Propanoic acid, 2-methyl-, 2,4-hexadien-1-yl ester
EINECS 240-551-6
3,5-Hexadienyl isobutyrate
2,4-Hexadienyl 2-methylpropanoate
Isobutyric acid, 2,4-hexadienyl ester
2-Methylpropanoic acid 2,4-hexadienyl ester
NSC 195147
Sorbyl isobutyrate
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Hexadienyl Isobutyrate allowed in the EU?
Hexadienyl Isobutyrate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hexadienyl Isobutyrate do in cosmetics?
Hexadienyl Isobutyrate functions as: Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 16491-24-0.
Is Hexadienyl Isobutyrate used outside cosmetics?
Hexadienyl Isobutyrate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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