Is Hesperetin safe in cosmetics?
Hesperetin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Hesperetin
Also known as: EINECS 208-290-2, UNII-Q9Q3D557F1, (-)-(S)-hesperetin, (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one, (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (+7 more)
INCI: HESPERETIN
Hesperetin (CAS 520-33-2) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning, skin protecting, anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 520-33-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant, skin conditioning, skin protecting, anti-inflammatory
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-2,3-dihydrochromen-4-one
InChIKey
AIONOLUJZLIMTK-AWEZNQCLSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific prohibition or restriction under 21 CFR; general safety clause applies
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Hesperetin.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Flavouring and nutrient
Softener and conditioner
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Hesperetin.
Regulatory Flags
endocrine_disruptor
fda_food_additive
Known Synonyms
EINECS 208-290-2
UNII-Q9Q3D557F1
(-)-(S)-hesperetin
(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
5,7, 3'-Trihydroxy-4'-methoxyflavanone
Cyanidanon 4'-Methyl Ether 1626
Flavanone, 3',5, 7-trihydroxy-4'-methoxy- (VAN)
Flavanone, 3',5,7-trihydroxy-4'-methoxy- (VAN) (8CI)
Hesperin
Prestwick_908
YSO2
Chemical Function
Antioxidant
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
HESPERETIN
ChEMBL ID
CHEMBL399121
Max Phase
0.5
Frequently Asked Questions
Is Hesperetin allowed in the EU?
Hesperetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Hesperetin do in cosmetics?
Hesperetin functions as: Antioxidant, skin conditioning, skin protecting, anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 520-33-2.
Is Hesperetin used outside cosmetics?
Hesperetin also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Hesperetin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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