What is the NOAEL for Hesperetin?
Hesperetin has 4 NOAEL studies in the database. The lowest reported value is Q9Q3D557F1 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Hesperetin
Also known as: EINECS 208-290-2, UNII-Q9Q3D557F1, (-)-(S)-hesperetin, (2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one, (S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one (+7 more)
CAS 520-33-2
Hesperetin (CAS 520-33-2) is a chemical substance. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
18 fields
Name
Hesperetin
CAS Number
520-33-2
DTXSID
DTXSID4022319
Molecular Formula
C16H14O6
InChI Key
AIONOLUJZLIMTK-AWEZNQCLSA-N
Monoisotopic Mass
302.079038
Synonyms
EINECS 208-290-2UNII-Q9Q3D557F1(-)-(S)-hesperetin(2S)-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one(S)-2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one5,7, 3'-Trihydroxy-4'-methoxyflavanoneCyanidanon 4'-Methyl Ether 1626Flavanone, 3',5, 7-trihydroxy-4'-methoxy- (VAN)Flavanone, 3',5,7-trihydroxy-4'-methoxy- (VAN) (8CI)HesperinPrestwick_908YSO2
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
4 records
AntioxidantSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Europe | European Commission | Fl@vis |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| Q9Q3D557F1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q9Q3D557F1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q9Q3D557F1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| Q9Q3D557F1 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Antioxidant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
HESPERETIN
ChEMBL Phase
0.5
Adverse Events
0
Bioactivity
16
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Hesperetin?
Hesperetin appears on 3 regulatory/inventory lists including food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Europe, Canada; pharmaceutical. Source: EPA CPDat.
Is Hesperetin used in cosmetics?
Yes, Hesperetin is also indexed as a cosmetic ingredient under the name Hesperetin. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Hesperetin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Hesperetin used outside industrial chemicals?
Hesperetin also appears in cosmetics, pharmaceutical, food safety, cannabis databases.