Is HC Blue No. 15 safe in cosmetics?
HC Blue No. 15 has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 10 toxicological study endpoint(s) are available in our database.
HC Blue No. 15
Also known as: Benzenamine, 4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)methyl]-2,6-dimethyl-, phosphate (1:1), EINECS 277-929-5, 2,6-Xylidine, 4-(2,6-dichloro-alpha-(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)benzyl)-, dihydrogen phosphate, UNII-62LA9436UJ, 4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethylcyclohexa-2,5-dien-1-ylidene)methyl]-2,6-xylidine phosphate (1:1) (+2 more)
INCI: HC BLUE NO. 15
HC Blue No. 15 (CAS 74578-10-2) is a cosmetic cosmetic ingredient functioning as Hair dyeing (oxidative hair dye, non-reacting component). Reported NOAEL =0.0003 mg/kg bw/d in rat (SCCS_vision_codex); EU Regulation 1223/2009 status: prohibited, max 0.2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 74578-10-2 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
HC Blue No. 15 is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H318, H373, H400, H410).
Source: Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair dyeing (oxidative hair dye, non-reacting component)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
4-[(2,6-dichlorophenyl)-(4-imino-3,5-dimethylcyclohexa-2,5-dien-1-ylidene)methyl]-2,6-dimethylaniline;phosphoric acid
InChIKey
RJKYUPXJBBSRML-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
EU Max Conc.
0.2%
US US Status
permitted
US Notes
MoS
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for HC Blue No. 15.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
10 study endpoints found for HC Blue No. 15. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =0.0003 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0003 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0003 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.0003 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.02 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.02 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.02 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =0.02 mg/kg bw/d | oral | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =3 mg/kg bw/day | - | rat | dermal absorption | SCCS_vision_codex |
| NOAEL | =3 mg/kg bw/day | - | rat | dermal absorption | SCCS_vision_codex |
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: (a) Hair dye substance in oxidative hair dye products (b) Hair dye substance in non-oxidative hair dye products. Max: (b) 0,2 %.
BRIN Brazil/India Cosmetics
India: Restricted · max (b) 0,2 %
Expanded Dermal Absorption Data
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
Aggregated DA Values (2 records across 5 sources)
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured_sccs_opinion | 0.11% | - | - | SCCS/1440/11 |
| measured_sccs_opinion | 0.11% | - | - | SCCS/1440/11 |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
hair_dye
{"cas_number": "74578-10-2", "ingredient_class": "direct_dye", "chemical_class": "anthraquinone", "molecular_weight_Da": "268.27", "color_result_on_hair": "Blue", "shade_range": "fashion_color", "primary_function": "direct_deposit", "requires_developer": "no", "lift_capability_levels": "0", "deposit_only": "yes", "permanence": "semi_permanent", "wash_fastness_shampoos": "6-12", "light_fastness": "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Regulatory List Membership (1)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for HC Blue No. 15.
Regulatory Flags
eu_cosing_listed
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to HC Blue No. 15 by CAS number or substance name.
Studies
24
Lowest NOAEL
0.0003
Highest NOAEL
4
Units vary across source rows: mg/kg bw/day, mg/kg bw, mg/kg bw/d
SCCS_vision_codex
Dermal Absorption
View details ->| Absorption % | Method | Vehicle |
|---|---|---|
| 0.11% | SCCS opinion extraction | - |
| 0.11% | SCCS opinion extraction | - |
Known Synonyms
Benzenamine, 4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)methyl]-2,6-dimethyl-, phosphate (1:1)
EINECS 277-929-5
2,6-Xylidine, 4-(2,6-dichloro-alpha-(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)benzyl)-, dihydrogen phosphate
UNII-62LA9436UJ
4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethylcyclohexa-2,5-dien-1-ylidene)methyl]-2,6-xylidine phosphate (1:1)
EC No.: 277-929-5
277-929-5
Chemical Function
Dye
Regulatory Lists
Europe; Personal care; restricted
Europe; Personal care; restricted
Frequently Asked Questions
Is HC Blue No. 15 allowed in the EU?
HC Blue No. 15 EU regulatory status: prohibited. Maximum allowed concentration: 0.2%. This is based on EU Regulation 1223/2009 and its amendments.
What does HC Blue No. 15 do in cosmetics?
HC Blue No. 15 functions as: Hair dyeing (oxidative hair dye, non-reacting component). It is classified as a cosmetic ingredient in our database. CAS number: 74578-10-2.
What is the NOAEL for HC Blue No. 15?
The NOAEL (No Observed Adverse Effect Level) for HC Blue No. 15 is =0.0003 mg/kg bw/d based on a dermal absorption study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Is HC Blue No. 15 used outside cosmetics?
HC Blue No. 15 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does HC Blue No. 15 have different safety status in cosmetics vs industrial chemicals?
HC Blue No. 15 is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H318, H373, H400, H410).
Compliance Tools
Check HC Blue No. 15 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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