NOAEL Data Cosmetic Ingredient

HC Blue No. 15

Also known as: Benzenamine, 4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)methyl]-2,6-dimethyl-, phosphate (1:1), EINECS 277-929-5, 2,6-Xylidine, 4-(2,6-dichloro-alpha-(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)benzyl)-, dihydrogen phosphate, UNII-62LA9436UJ, 4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethylcyclohexa-2,5-dien-1-ylidene)methyl]-2,6-xylidine phosphate (1:1) (+2 more)

CAS 74578-10-2

HC Blue No. 15 (CAS 74578-10-2) is a chemical substance. Key regulatory status: 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.

View cosmetic safety profile for HC Blue No. 15 →

Cross-Vertical Regulatory Divergence

HC Blue No. 15 is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H318, H373, H400, H410).

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status/eu_max; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 13 fields

Name

HC Blue No. 15

CAS Number

74578-10-2

DTXSID

DTXSID3072793

Molecular Formula

C23H22Cl2N2.H3O4P

InChI Key

RJKYUPXJBBSRML-BCNYPWFVSA-N

Monoisotopic Mass

494.0929

Synonyms

Benzenamine, 4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)methyl]-2,6-dimethyl-, phosphate (1:1)EINECS 277-929-52,6-Xylidine, 4-(2,6-dichloro-alpha-(4-imino-3,5-dimethyl-2,5-cyclohexadien-1-ylidene)benzyl)-, dihydrogen phosphateUNII-62LA9436UJ4-[(2,6-dichlorophenyl)(4-imino-3,5-dimethylcyclohexa-2,5-dien-1-ylidene)methyl]-2,6-xylidine phosphate (1:1)EC No.: 277-929-5277-929-5

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 2 records

Dye

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 2 records

List	Keyword	Source
Europe; Personal care; restricted	European Commission	CosIng
Europe; Personal care; restricted	European Commission	CosIng

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 50 of 50 studies

Value	Unit	Endpoint	Route	Species	Source
4	mg/kg bw	-	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw	-	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
62LA9436UJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
62LA9436UJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
62LA9436UJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
62LA9436UJ	UNII	FDA UNII substance identifier	-	-	openFDA substances
4	mg/kg bw/day	LOAEL	oral	rat	COSMOS_DB
=0.0003	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.0003	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.0003	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.0003	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.02	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.02	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.02	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.02	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
1	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
=1.76	μg/cm	NOAEL	oral	-	SCCS_vision_codex
=1.76	μg/cm	NOAEL	oral	-	SCCS_vision_codex
=1.76	μg/cm	NOAEL	oral	-	SCCS_vision_codex
=1.76	μg/cm	NOAEL	oral	-	SCCS_vision_codex
=3	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=3	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=3	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=3	mg/kg bw/day	NOAEL	-	rat	SCCS_vision_codex
=4	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=4	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=4	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=4	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=4	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=4	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=4	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=4	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=4	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=4	mg/kg bw/day	NOAEL	-	-	SCCS_vision_codex
=4	mg/kg bw	NOAEL	oral	-	SCCS_vision_codex
=4	mg/kg bw/d	NOAEL	oral	rat	SCCS_vision_codex
=0.0003	mg/kg bw/d	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=0.02	mg/kg bw/d	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
3	mg/kg bw/day	dermal absorption	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
3	mg/kg bw/day	dermal absorption	-	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=4	mg/kg bw/d	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
=4	mg/kg bw/d	dermal absorption	oral	rat	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw/day	genotoxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw/day	genotoxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw/day	genotoxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw/day	genotoxicity	-	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
1.76	μg/cm	repeated dose toxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw/day	repeated dose toxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw/day	repeated dose toxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies
4	mg/kg bw/day	repeated dose toxicity	oral	-	UnifiedCodex:SCCS_SHADOW:beta.noael_studies

Showing 50 of 50 studies

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

prohibited

Max

0.2%

Frequently Asked Questions

What is the NOAEL for HC Blue No. 15?

HC Blue No. 15 has 50 NOAEL studies in the database. The lowest reported value is 4 mg/kg bw via oral. Source: UnifiedCodex:SCCS_SHADOW:beta.noael_studies.

What regulatory lists include HC Blue No. 15?

HC Blue No. 15 appears on 1 regulatory/inventory list including Europe; Personal care; restricted. Source: EPA CPDat.

Is HC Blue No. 15 used in cosmetics?

Yes, HC Blue No. 15 is also indexed as a cosmetic ingredient under the name HC Blue No. 15. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for HC Blue No. 15 come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.

Does HC Blue No. 15 have different safety status in cosmetics vs industrial chemicals?

HC Blue No. 15 is prohibited in EU cosmetics at max 0.2% but has active industrial GHS classifications (H318, H373, H400, H410).

Is HC Blue No. 15 used outside industrial chemicals?

HC Blue No. 15 also appears in cosmetics databases.