Is Guaiene safe in cosmetics?
Guaiene has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Guaiene
Also known as: Azulene, 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-, (1S-cis)-, EINECS 201-860-1, 1,2,3,4,5,6,7,8-Octahydro-1,4-dimethyl-7-(1-methylethylidene)-azulene, (1S,cis), UNII-1D018Q907T
INCI: GUAIENE
Guaiene (CAS 88-84-6) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 88-84-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Guaiene is classified GHS Danger (H304, H315, H319) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(1S,4S)-1,4-dimethyl-7-propan-2-ylidene-2,3,4,5,6,8-hexahydro-1H-azulene
InChIKey
GIBQERSGRNPMEH-RYUDHWBXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Guaiene.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
1350 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [5] Epstein WL (1976): Report to RIFM, 27 August, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
| HRIPT | - | 0 | 11811.02 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1347
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
GUAIENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Guaiene.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Azulene, 1,2,3,4,5,6,7,8-octahydro-1,4-dimethyl-7-(1-methylethylidene)-, (1S-cis)-
EINECS 201-860-1
1,2,3,4,5,6,7,8-Octahydro-1,4-dimethyl-7-(1-methylethylidene)-azulene, (1S,cis)
UNII-1D018Q907T
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
Europe
IFRA Transparency
detected; Europe; Personal care - sexual wellness
detected; Europe; Personal care - sexual wellness
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Guaiene allowed in the EU?
Guaiene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Guaiene do in cosmetics?
Guaiene functions as: Fragrance ingredient. It is classified as a cosmetic ingredient in our database. CAS number: 88-84-6.
Is Guaiene used outside cosmetics?
Guaiene also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Guaiene have different safety status in cosmetics vs industrial chemicals?
Guaiene is classified GHS Danger (H304, H315, H319) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Guaiene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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