Is 2-Ethylbutyric Acid safe in cosmetics?
2-Ethylbutyric Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
2-Ethylbutyric Acid
Also known as: 4-02-00-00950, Acetic acid, diethyl-, BRN 1098634, Diethylacetic acid, EINECS 201-796-4 (+10 more)
INCI: 2-ETHYLBUTYRIC ACID
2-Ethylbutyric Acid (CAS 88-09-5) is a cosmetic cosmetic ingredient functioning as Perfuming (acidic odor type). NOAEL 10 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 88-09-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
2-Ethylbutyric Acid is classified GHS Danger (H311, H319, H227, H318, H361, H402) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Perfuming (acidic odor type)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
2-ethylbutanoic acid
InChIKey
OXQGTIUCKGYOAA-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FEMA GRAS; not individually restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for 2-Ethylbutyric Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for 2-Ethylbutyric Acid. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =10 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =250 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for 2-Ethylbutyric Acid across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
257
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ETHYLBUTYRIC ACID | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/37 | FAS 40-JECFA 49/189
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for 2-Ethylbutyric Acid.
Regulatory Flags
fragrance-component
natural-origin
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to 2-Ethylbutyric Acid by CAS number or substance name.
Studies
17
Lowest NOAEL
10 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
4-02-00-00950
Acetic acid, diethyl-
BRN 1098634
Diethylacetic acid
EINECS 201-796-4
2-Ethyl butanoic acid
2-Ethylbutanoic acid
alpha-Ethylbutyric acid
alpha-Ethylbuytyric acid
FEMA No. 2429
NSC 11765
3-Pentanecarboxylic acid
Kyselina diethyloctova
UNII-IDY8B990KE
Butanoic acid, 2-ethyl-
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL184290
Frequently Asked Questions
Is 2-Ethylbutyric Acid allowed in the EU?
2-Ethylbutyric Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does 2-Ethylbutyric Acid do in cosmetics?
2-Ethylbutyric Acid functions as: Perfuming (acidic odor type). It is classified as a cosmetic ingredient in our database. CAS number: 88-09-5.
What is the NOAEL for 2-Ethylbutyric Acid?
The NOAEL (No Observed Adverse Effect Level) for 2-Ethylbutyric Acid is =10 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is 2-Ethylbutyric Acid used outside cosmetics?
2-Ethylbutyric Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does 2-Ethylbutyric Acid have different safety status in cosmetics vs industrial chemicals?
2-Ethylbutyric Acid is classified GHS Danger (H311, H319, H227, H318, H361, H402) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check 2-Ethylbutyric Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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