Is Glycine HCl safe in cosmetics?
Glycine HCl has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Glycine HCl
Also known as: Aminoacetic acid hydrochloride, Glycine, hydrochloride, Glycine, hydrochloride (1:1), EINECS 227-841-8, Glycocoll hydrochloride (+1 more)
INCI: GLYCINE HCL
Glycine HCl (CAS 6000-43-7) is a cosmetic cosmetic ingredient functioning as Buffering — controls pH of cosmetic products. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 6000-43-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Glycine HCl is classified GHS Danger (H314, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu status; Chemicals: ghs classifications.signal word/hazard statement code
Function
Buffering — controls pH of cosmetic products
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
2-aminoacetic acid;hydrochloride
InChIKey
IVLXQGJVBGMLRR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — glycine is GRAS (21 CFR §170.30); HCl salt not separately restricted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glycine HCl.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Glycine HCl.
Known Synonyms
Aminoacetic acid hydrochloride
Glycine, hydrochloride
Glycine, hydrochloride (1:1)
EINECS 227-841-8
Glycocoll hydrochloride
UNII-225ZLC74HX
Chemical Function
pH regulating agent
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Glycine HCl allowed in the EU?
Glycine HCl EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glycine HCl do in cosmetics?
Glycine HCl functions as: Buffering — controls pH of cosmetic products. It is classified as a cosmetic ingredient in our database. CAS number: 6000-43-7.
Is Glycine HCl used outside cosmetics?
Glycine HCl also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Glycine HCl have different safety status in cosmetics vs industrial chemicals?
Glycine HCl is classified GHS Danger (H314, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Glycine HCl compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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