Is Glyceryl Thioglycolate safe in cosmetics?
Glyceryl Thioglycolate has a safety rating of "MODERATE" in our database. EU status: prohibited. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Glyceryl Thioglycolate
Also known as: Acetic acid, mercapto-, monoester with 1,2,3-propanetriol, Acetic acid, 2-mercapto-, monoester with 1,2,3-propanetriol, Acetic acid, mercapto-, ester with glycerol, Acetic acid, mercapto-, monoester with glycerol, Glycerin monothioglycolate (+9 more)
INCI: GLYCERYL THIOGLYCOLATE
Glyceryl Thioglycolate (CAS 30618-84-9) is a cosmetic cosmetic ingredient functioning as Hair waving/straightening agent (thioglycolic acid ester). NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 30618-84-9 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Glyceryl Thioglycolate is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H312, H317).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Hair waving/straightening agent (thioglycolic acid ester)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,3-dihydroxypropyl 2-sulfanylacetate
InChIKey
DOGJSOZYUGJVKS-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific CFR restriction; FDA monitors under MoCRA general provisions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glyceryl Thioglycolate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Glyceryl Thioglycolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =50 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =150 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Glyceryl Thioglycolate across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | restricted | 8 | Hair waving products |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Hair waving or straightening
Expert Verdict
Expert safety assessment and concern-level summary for Glyceryl Thioglycolate.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Glyceryl Thioglycolate by CAS number or substance name.
Studies
2
Lowest NOAEL
50 mg/kg bw/day
Highest NOAEL
150 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
Acetic acid, mercapto-, monoester with 1,2,3-propanetriol
Acetic acid, 2-mercapto-, monoester with 1,2,3-propanetriol
Acetic acid, mercapto-, ester with glycerol
Acetic acid, mercapto-, monoester with glycerol
Glycerin monothioglycolate
Glyceryl monothioglycolate
Acide mercaptoacetique, monoester avec le propane-1,2,3-triol
mercaptoacetic acid, monoester with propane-1,2,3-triol
acide mercaptoacetique, monoester avec propane-1,2,3-triol
Mercaptoessigsaure, Monoester mit Propan-1,2,3-triol
acido mercaptoacetico, monoester con propano-1,2,3-triol
EC 250-264-8
UNII-0FWE72AF2P
EINECS 250-264-8
Chemical Function
Hair waving or straightening
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Glyceryl Thioglycolate allowed in the EU?
Glyceryl Thioglycolate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Glyceryl Thioglycolate do in cosmetics?
Glyceryl Thioglycolate functions as: Hair waving/straightening agent (thioglycolic acid ester). It is classified as a cosmetic ingredient in our database. CAS number: 30618-84-9.
What is the NOAEL for Glyceryl Thioglycolate?
The NOAEL (No Observed Adverse Effect Level) for Glyceryl Thioglycolate is =50 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Glyceryl Thioglycolate used outside cosmetics?
Glyceryl Thioglycolate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Glyceryl Thioglycolate have different safety status in cosmetics vs industrial chemicals?
Glyceryl Thioglycolate is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H312, H317).
Compliance Tools
Check Glyceryl Thioglycolate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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