What is the NOAEL for Glycerol monomercaptoacetate?
Glycerol monomercaptoacetate has 24 NOAEL studies in the database. The lowest reported value is 1 ug/mL via Dermal. Source: NTP_ICE_skin_sensitization.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Glycerol monomercaptoacetate
Also known as: Acetic acid, mercapto-, monoester with 1,2,3-propanetriol, Acetic acid, 2-mercapto-, monoester with 1,2,3-propanetriol, Acetic acid, mercapto-, ester with glycerol, Acetic acid, mercapto-, monoester with glycerol, Glycerin monothioglycolate (+9 more)
CAS 30618-84-9
Glycerol monomercaptoacetate (CAS 30618-84-9) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Glycerol monomercaptoacetate is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H312, H317).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
24
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
17 fields
Name
Glycerol monomercaptoacetate
CAS Number
30618-84-9
DTXSID
DTXSID2027965
Synonyms
Acetic acid, mercapto-, monoester with 1,2,3-propanetriolAcetic acid, 2-mercapto-, monoester with 1,2,3-propanetriolAcetic acid, mercapto-, ester with glycerolAcetic acid, mercapto-, monoester with glycerolGlycerin monothioglycolateGlyceryl monothioglycolateAcide mercaptoacetique, monoester avec le propane-1,2,3-triolmercaptoacetic acid, monoester with propane-1,2,3-triolacide mercaptoacetique, monoester avec propane-1,2,3-triolMercaptoessigsaure, Monoester mit Propan-1,2,3-triolacido mercaptoacetico, monoester con propano-1,2,3-triolEC 250-264-8
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
1 records
Hair waving or straightening
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 24 of 24 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 1 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 6.02 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 833.68 | ug/mL | CD86, EC150 | Dermal | - | NTP_ICE_skin_sensitization |
| 1.03 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 81.07 | ug/mL | CV70 | Dermal | - | NTP_ICE_skin_sensitization |
| 921.1 | ug/mL | CV75 | Dermal | - | NTP_ICE_skin_sensitization |
| 158.7 | uM | EC1.5 | Dermal | - | NTP_ICE_skin_sensitization |
| 4.7 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 4.7 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 4.7 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 4.7 | % | EC3 | Dermal | Mouse | NTP_ICE_skin_sensitization |
| 272.6 | uM | EC3 | Dermal | - | NTP_ICE_skin_sensitization |
| 0FWE72AF2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0FWE72AF2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0FWE72AF2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0FWE72AF2P | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 534.1 | uM | IC50 | Dermal | - | NTP_ICE_skin_sensitization |
| 53.4 | ratio | Imax | Dermal | - | NTP_ICE_skin_sensitization |
| =172 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =181 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =268 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =274 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =150 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 24 of 24 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Mercaptoacetic acid, monoester with propane-1,2,3-triol | 250-264-8 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Cosmetic Ingredient
Frequently Asked Questions
Is Glycerol monomercaptoacetate used in cosmetics?
Yes, Glycerol monomercaptoacetate is also indexed as a cosmetic ingredient under the name Glyceryl Thioglycolate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glycerol monomercaptoacetate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Glycerol monomercaptoacetate have different safety status in cosmetics vs industrial chemicals?
Glycerol monomercaptoacetate is prohibited in EU cosmetics but has active industrial GHS classifications (H301, H312, H317).
Is Glycerol monomercaptoacetate used outside industrial chemicals?
Glycerol monomercaptoacetate also appears in cosmetics databases.