Is Glutamine safe in cosmetics?
Glutamine has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Glutamine
Also known as: Levoglutamide, 4-04-00-03038, 2-Aminoglutaramic acid, L-, BRN 1723797, 2,5-Diamino-5-oxopentanoic acid, (S)- (+13 more)
INCI: GLUTAMINE
Glutamine (CAS 56-85-9) is a cosmetic cosmetic ingredient functioning as Hair conditioning / skin conditioning. NOAEL 833 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 56-85-9 →
Auto-generated CPSR Part A draft with source citations
Function
Hair conditioning / skin conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(2S)-2,5-diamino-5-oxopentanoic acid
InChIKey
ZDXPYRJPNDTMRX-VKHMYHEASA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — GRAS amino acid; not restricted under 21 CFR for cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glutamine.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Glutamine. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 3379 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =833 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =964 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =3259.4 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =3741.9 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Glutamine across SCCS product categories, with measured dermal absorption where available.
EPA ToxValDB — Toxicity Values
10 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >16000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | >16000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | ~16000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LEL | =5000 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| LEL | =5000 mg/kg-day | Rat | oral | short-term | ECHA IUCLID |
| NOAEL | =3741.9 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =3259.4 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =833 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| NOAEL | =964 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
| LEL | =4000 mg/kg-day | Rat | oral | chronic | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
3 property records from structured ingredient metadata.
acne
{"cas_number": "56-85-9", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-5", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_ac…
anti_aging
{"anti_aging_claim": "barrier-repair, hydration-plumping", "mechanism_of_action": "Building block for proteins, NMF component", "target_skin_layer": "epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "Int J Cosm…
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "barrier-support", "skin_benefit_secondary": "healing", "…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (2)
JECFA Number
1430
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
L-GLUTAMINE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | Not evaluated using the Procedure for the Safety Evaluation of Flavouring Agents; the substance is a macronutrient and a normal component of protein and, as such, human exposure through food is orders of magnitude higher than the anticipated level of exposure from use as a flavouring agent | TRS 92
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Anti-static agent
Flavouring and nutrient
Softener and conditioner
Regulatory List Membership (2)
EU Restricted for Children (Cosmetics)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Glutamine.
Regulatory Flags
eu_children_restricted
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Glutamine by CAS number or substance name.
Studies
5
Lowest NOAEL
833 mg/kg bw/day
Highest NOAEL
3741.9 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
Levoglutamide
4-04-00-03038
2-Aminoglutaramic acid, L-
BRN 1723797
2,5-Diamino-5-oxopentanoic acid, (S)-
EINECS 200-292-1
FEMA No. 3684
Miglu-P
Nutrestore
UNII-0RH81L854J
(2S)-2,5-diamino-5-oxopentanoate
(2S)-2,5-diamino-5-oxopentanoic acid
(2S)-2-amino-4-carbamoylbutanoate
(2S)-2-amino-4-carbamoylbutanoic acid
(S)-2,5-Diamino-5-oxopentanoate
(S)-2,5-diamino-5-oxopentanoic acid
Glumin
L-2-aminoglutaramic acid
Chemical Function
Anti-static agent
Softener and conditioner
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
pharmaceutical
active_ingredient; animal_products; Europe; pharmaceutical; residue
children; Europe; Personal care
children; Europe; Personal care
Europe
active_ingredient; Australia
Canada; consumer_product; Substances in Products - Canada (4/2014)
pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GLUTAMINE
ChEMBL ID
CHEMBL930
Max Phase
4
Adverse Event Associations
43
Frequently Asked Questions
Is Glutamine allowed in the EU?
Glutamine EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glutamine do in cosmetics?
Glutamine functions as: Hair conditioning / skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 56-85-9.
What is the NOAEL for Glutamine?
The NOAEL (No Observed Adverse Effect Level) for Glutamine is 3379 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is Glutamine used outside cosmetics?
Glutamine also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Glutamine compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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