What is the NOAEL for L-Glutamine?
L-Glutamine has 22 NOAEL studies in the database. The lowest reported value is 138.6 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
L-Glutamine
Also known as: Glutamine, Levoglutamide, 4-04-00-03038, 2-Aminoglutaramic acid, L-, BRN 1723797 (+14 more)
CAS 56-85-9
L-Glutamine (CAS 56-85-9) is a chemical substance. Key regulatory status: REACH registered, 14 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
22
SOURCE
chemical inventory jurisdictions
Regulatory lists
14
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
L-Glutamine
CAS Number
56-85-9
DTXSID
DTXSID1023100
Molecular Formula
C5H10N2O3
InChI Key
ZDXPYRJPNDTMRX-VKHMYHEASA-N
Monoisotopic Mass
146.069142
Synonyms
GlutamineLevoglutamide4-04-00-030382-Aminoglutaramic acid, L-BRN 17237972,5-Diamino-5-oxopentanoic acid, (S)-EINECS 200-292-1FEMA No. 3684Miglu-PNutrestoreUNII-0RH81L854J(2S)-2,5-diamino-5-oxopentanoate
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
14 records
Anti-static agentSoftener and conditionerFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
14 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| Europe | European Commission | Fl@vis |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 22 of 22 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =138.6 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 0RH81L854J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0RH81L854J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0RH81L854J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0RH81L854J | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=200 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =833 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =964 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =3259.4 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3379 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =3741.9 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <=4000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <=4000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
| <=4000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
| <=4000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
| <=4000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
| <=10000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| <=10000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
| <=10000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
| <=10000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
| <=10000 | mg/kg bw/day | NOEL | oral: gavage | rat (Sprague-Dawley; male/female) | FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z |
Showing 22 of 22 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Levoglutamide | 200-292-1 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLUTAMINE
ChEMBL Phase
4
Adverse Events
43
Bioactivity
3
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include L-Glutamine?
L-Glutamine appears on 9 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, pharmaceutical, active_ingredient; animal_products; Europe; pharmaceutical; residue, and 6 more. Source: EPA CPDat.
Is L-Glutamine used in cosmetics?
Yes, L-Glutamine is also indexed as a cosmetic ingredient under the name Glutamine. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for L-Glutamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is L-Glutamine used outside industrial chemicals?
L-Glutamine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.