NOAEL Studies Cosmetic Ingredient

Glutamine NOAEL Studies

INCI: GLUTAMINE

CAS: 56-85-9

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 3379 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=10000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 4 weeks repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 30-day oral toxicity study in rats_1 - 52b030dd-5446-4eb4-ba2c-ab28d8a07b49/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: haematology: no abnormal phenotype detected
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=4000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 180 days repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 180-day oral toxicity study in rats_2 - b961efd4-1ef6-47fb-a1de-808aab8f5333/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: gross pathology: no abnormal phenotype detected
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=10000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 4 weeks repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 30-day oral toxicity study in rats_1 - 52b030dd-5446-4eb4-ba2c-ab28d8a07b49/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: haematology: no abnormal phenotype detected
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=4000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 180 days repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 180-day oral toxicity study in rats_2 - b961efd4-1ef6-47fb-a1de-808aab8f5333/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: gross pathology: no abnormal phenotype detected
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=10000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 4 weeks repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 30-day oral toxicity study in rats_1 - 52b030dd-5446-4eb4-ba2c-ab28d8a07b49/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: haematology: no abnormal phenotype detected
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=4000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 180 days repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 180-day oral toxicity study in rats_2 - b961efd4-1ef6-47fb-a1de-808aab8f5333/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: gross pathology: no abnormal phenotype detected
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=10000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 4 weeks repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 30-day oral toxicity study in rats_1 - 52b030dd-5446-4eb4-ba2c-ab28d8a07b49/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: haematology: no abnormal phenotype detected
FDA_Toxicity_f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z NOEL <=4000 mg/kg bw/day rat (Sprague-Dawley; male/female) oral: gavage 180 days repeated dose toxicity oral f8414ef0-fbc3-4daf-906d-849dfbdf25d5_dossier.i6z - RepeatedDoseToxicityOral - 180-day oral toxicity study in rats_2 - b961efd4-1ef6-47fb-a1de-808aab8f5333/da7a5559-7e43-4eba-b7ac-73b1d3ac80cb - basis: gross pathology: no abnormal phenotype detected
ToxValDB_ECHA_IUCLID 8 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LEL =5000 mg/kg bw/day Rat oral short-term; 4 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c937e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17119/7/6/2?documentUUID=0094f36b-8224-4097-9aee-628350e515a0; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15847238:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1631a28d1f2ae695817c6ca845670014
ToxValDB_ECHA_IUCLID LEL >=200 mg/kg bw/day Rat oral chronic; 180 days chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c939e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=da7a5559-7e43-4eba-b7ac-73b1d3ac80cb; YEAR=0; ORIGINAL_YEAR=0; TOXICOLOGICAL_EFFECT=histopathology: non-neoplastic: hepatic steatosis; TOXICOLOGICAL_EFFECT_CATEGORY=nonneoplastic histopathology; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841993_15841994_15849573:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8e42efaa5794f242da4ae36e2e6e400a
ToxValDB_ECHA_IUCLID NOAEL =3741.9 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c93b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17119/7/6/2?documentUUID=0094f36b-8224-4097-9aee-628350e515a0; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15848453:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_9e4403401db1e42e95469c9886712ace
ToxValDB_ECHA_IUCLID NOAEL =3259.4 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c93b7; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17119/7/6/2?documentUUID=0094f36b-8224-4097-9aee-628350e515a0; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15848495:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3e10b21ff3c49945c11edd574d3a3c9c
ToxValDB_ECHA_IUCLID NOAEL =833 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9392; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17119/7/6/2?documentUUID=0094f36b-8224-4097-9aee-628350e515a0; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15849571:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_37ae87b230a82f86253a93a8b84118af
ToxValDB_ECHA_IUCLID NOAEL =964 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9392; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17119/7/6/2?documentUUID=0094f36b-8224-4097-9aee-628350e515a0; YEAR=2003; ORIGINAL_YEAR=2003; STUDY_GROUP=ECHA IUCLID:15849572:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_16687b0c95922be5bd193f3f5e3e3588
ToxValDB_ECHA_IUCLID NOEL <=10000 mg/kg bw/day Rat oral short-term; 4 weeks short-term STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c9389; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=da7a5559-7e43-4eba-b7ac-73b1d3ac80cb; TOXICOLOGICAL_EFFECT=clinical biochemistry: no abnormal phenotype detected|gross pathology: no abnormal phenotype detected|haematology: no abnormal phenotype detected|organ weights and organ / body weight ratios: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected|water consumption and compound intake: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15835145_15849569:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1faff3533457e61b06c732ebf9269674
ToxValDB_ECHA_IUCLID NOEL <=4000 mg/kg bw/day Rat oral chronic; 180 days chronic STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae72e4b0a7c65d1c939e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://iuclid6.echa.europa.eu/us-fda-toxicity-data?documentUUID=da7a5559-7e43-4eba-b7ac-73b1d3ac80cb; TOXICOLOGICAL_EFFECT=clinical signs: no abnormal phenotype detected|gross pathology: no abnormal phenotype detected|mortality: no abnormal phenotype detected|organ weights and organ / body weight ratios: no abnormal phenotype detected|urinalysis: no abnormal phenotype detected; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15841993_15841994_15849573:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_d8d4d069bc0a0e185d3ec506dd81e01c
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =138.6 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632398:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_1fb87d3758d0cdefc91a521ab6141213
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 0RH81L854J UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0RH81L854J"}
openFDA substances FDA UNII substance identifier 0RH81L854J UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0RH81L854J"}
openFDA substances FDA UNII substance identifier 0RH81L854J UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0RH81L854J"}
openFDA substances FDA UNII substance identifier 0RH81L854J UNII - - - chemical {"approval_status":null,"molecular_formula":"C5H10N2O3","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"0RH81L854J"}