Is Glucuronic Acid safe in cosmetics?
Glucuronic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Glucuronic Acid
Also known as: acide glucuronique, Glucuronsaure, acido glucuronico
INCI: GLUCURONIC ACID
Glucuronic Acid (CAS 576-37-4) is a cosmetic cosmetic ingredient functioning as Buffering, Chelating, Humectant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 576-37-4 →
Auto-generated CPSR Part A draft with source citations
Function
Buffering, Chelating, Humectant
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S,3S,4S,5R)-2,3,4,5-tetrahydroxy-6-oxohexanoic acid
InChIKey
IAJILQKETJEXLJ-QTBDOELSSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No CIR monograph; not independently GRAS listed; endogenous human metabolite produced via hepatic glucuronidation
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Glucuronic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
2 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "hydration-plumping, barrier-repair", "mechanism_of_action": "Exfoliation, cell turnover acceleration, keratolytic", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "40", "double_blind": "No", "placebo_controlled": "Yes", "publ…
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "acceptable", "dehydrated": "acceptable", "skin_benefit_primary": "detoxifying", "skin_benefit_secondary": "antioxidant", "…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Humectant
pH regulating agent
Expert Verdict
Expert safety assessment and concern-level summary for Glucuronic Acid.
Regulatory Flags
data-gap
endogenous-metabolite
no-sccs-opinion
no-cir-monograph
humectant
chelating
buffering
Known Synonyms
acide glucuronique
Glucuronsaure
acido glucuronico
Chemical Function
Humectant
Chelating agent
pH regulating agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Frequently Asked Questions
Is Glucuronic Acid allowed in the EU?
Glucuronic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Glucuronic Acid do in cosmetics?
Glucuronic Acid functions as: Buffering, Chelating, Humectant. It is classified as a cosmetic ingredient in our database. CAS number: 576-37-4.
Compliance Tools
Check Glucuronic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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