Is Gluconic Acid safe in cosmetics?
Gluconic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Gluconic Acid
Also known as: Gluconic acid, D-, Gluconal GA-50, Maltonic acid, 4-03-00-01255, BRN 1726055 (+15 more)
INCI: GLUCONIC ACID
Gluconic Acid (CAS 526-95-4) is a cosmetic active ingredient functioning as Exfoliant. EU Regulation 1223/2009 status: permitted, max 50%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 526-95-4 →
Auto-generated CPSR Part A draft with source citations
Regulatory Status
EU EU Status
permitted
EU Max Conc.
50%
US US Status
permitted
US Notes
CIR: S - IJT 38(S1):5-38, 2019
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Gluconic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Hazard Statements
No hazard classification according to GHS criteria
EPA ToxValDB — Toxicity Values
3 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | dermal | acute | ECHA IUCLID |
| LOEL | =125.4 mg/L | Mouse | oral | short-term | ECOTOX |
| NOEL | =125.4 mg/L | Mouse | oral | short-term | ECOTOX |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
6 property records from structured ingredient metadata.
anti_pollution
{"cas_number": "526-95-4", "ingredient_class": "heavy_metal_chelator", "primary_mechanism": "chelation", "pollution_types_targeted": "heavy_metals", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB…
concentration
{"min_concentration_pct": "1.0", "max_concentration_pct": "5.0", "typical_concentration_pct": "3.0", "product_type": "Serum", "function_at_concentration": "Gentle exfoliation, chelating", "source": "Supplier TDS"}
microbiome
{"cas_number": "526-95-4", "ingredient_class": "postbiotic", "microbial_source_genus": "Lactobacillus", "microbial_source_species": "various", "fermentation_substrate": "glucose", "live_organism_content": "no", "bioactive_components": "organic_acids", "molecular_weight_range_Da": "196", "pH_of_ingredient": "2.5-4.5", "mechanism_of_action": "pH_modulation/antioxidant", "skin_microbiome_effect": "ba…
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "normal", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_children_products_eu": "no", "banned…
ph_stability
{"optimal_ph_min": "3.5", "optimal_ph_max": "5.5", "stable_ph_min": "3.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "ph_dependent_function": "Gentle PHA; chelator", "formulation_note": "From gluconolactone hydrolysis", "source": "Pure & Care 2022"}
preservative
{"preservative_class": "Organic acid", "antimicrobial_spectrum_bacteria_gp": "Weak", "antimicrobial_spectrum_bacteria_gn": "Weak", "antimicrobial_spectrum_yeast": "Weak", "antimicrobial_spectrum_mold": "Weak", "mic_staph_aureus_ppm": "4000", "mic_e_coli_ppm": "4000", "mic_pseudomonas_ppm": "4000", "mic_candida_albicans_ppm": "4000", "mic_aspergillus_niger_ppm": "4000", "challenge_test_pass_concent…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Chelating agent
Flavouring and nutrient
Fragrance
Pharmaceutical
Processing aids not otherwise specified
Solvent
Regulatory List Membership (2)
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Gluconic Acid.
Regulatory Flags
epa_safer_alternative
fda_food_additive
Known Synonyms
Gluconic acid, D-
Gluconal GA-50
Maltonic acid
4-03-00-01255
BRN 1726055
EINECS 208-401-4
(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid
2,3,4,5,6-Pentahydroxy-hexanoate
2,3,4,5,6-Pentahydroxy-hexanoic acid
2,3,4,5,6-Pentahydroxyhexanoate
2,3,4,5,6-Pentahydroxyhexanoic acid
D-Glukonsaeure
Dextronate
GCO
Glosanto
Gluconate
Glycogenate
Glyconate
Hexonic acid
Maltonate
Chemical Function
Chelating agent
Fragrance
Flavouring and nutrient
Pharmaceutical
Solvent
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GLUCONIC ACID
ChEMBL ID
CHEMBL464345
Frequently Asked Questions
Is Gluconic Acid allowed in the EU?
Gluconic Acid EU regulatory status: permitted. Maximum allowed concentration: 50%. This is based on EU Regulation 1223/2009 and its amendments.
What does Gluconic Acid do in cosmetics?
Gluconic Acid functions as: Exfoliant. It is classified as a Active Ingredient in our database. CAS number: 526-95-4.
Is Gluconic Acid used outside cosmetics?
Gluconic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Gluconic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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