What is the NOAEL for D-Gluconic acid?
D-Gluconic acid has 6 NOAEL studies in the database. The lowest reported value is 59 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
D-Gluconic acid
Also known as: Gluconic acid, D-, Gluconal GA-50, Maltonic acid, 4-03-00-01255, BRN 1726055 (+15 more)
CAS 526-95-4
D-Gluconic acid (CAS 526-95-4) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
D-Gluconic acid
CAS Number
526-95-4
DTXSID
DTXSID8027169
Molecular Formula
C6H12O7
InChI Key
RGHNJXZEOKUKBD-SQOUGZDYSA-N
Monoisotopic Mass
196.058303
Synonyms
Gluconic acid, D-Gluconal GA-50Maltonic acid4-03-00-01255BRN 1726055EINECS 208-401-4(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoic acid2,3,4,5,6-Pentahydroxy-hexanoate2,3,4,5,6-Pentahydroxy-hexanoic acid2,3,4,5,6-Pentahydroxyhexanoate2,3,4,5,6-Pentahydroxyhexanoic acidD-Glukonsaeure
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Hazard Statements | No hazard classification according to GHS criteria |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
21 records
Chelating agentFragranceFlavouring and nutrientPharmaceuticalSolventProcessing aids not otherwise specified
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| pharmaceutical | US International Trade Commission | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =59 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| R4R8J0Q44B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4R8J0Q44B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4R8J0Q44B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| R4R8J0Q44B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =125.4 | mg/L | LOEL | oral | Mouse | ToxValDB_ECOTOX |
Showing 6 of 6 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | D-gluconic acid | 208-401-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
50%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GLUCONIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include D-Gluconic acid?
D-Gluconic acid appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), SCIL (9/2019), and 1 more. Source: EPA CPDat.
Is D-Gluconic acid used in cosmetics?
Yes, D-Gluconic acid is also indexed as a cosmetic ingredient under the name Gluconic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D-Gluconic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Is D-Gluconic acid used outside industrial chemicals?
D-Gluconic acid also appears in cosmetics, pharmaceutical, food safety databases.