Is Gentisic Acid safe in cosmetics?
Gentisic Acid has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Antioxidant
Gentisic Acid
Also known as: 4-10-00-01441, BRN 2209119, EINECS 207-718-5, Gentisate, Salicylic acid, 5-hydroxy- (+13 more)
INCI: GENTISIC ACID
Gentisic Acid (CAS 490-79-9) is a cosmetic antioxidant functioning as Skin Conditioning, Antioxidant, Skin-Lightening, Antimicrobial. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 490-79-9 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Antioxidant, Skin-Lightening, Antimicrobial
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2,5-dihydroxybenzoic acid
InChIKey
WXTMDXOMEHJXQO-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not reviewed by CIR as standalone ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Gentisic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =4500 mg/kg | Mouse | oral | - | ChemIDplus |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Gentisic Acid.
Known Synonyms
4-10-00-01441
BRN 2209119
EINECS 207-718-5
Gentisate
Salicylic acid, 5-hydroxy-
Acido 2,5-diidrossibenzoico
Acidum gentisicum
Kyselina 2,5-dihydroxybenzoova
Kyselina gentisinova
UNII-VP36V95O3T
2,5-Dioxybenzoate
3,6-Dihydroxybenzoate
5-Hydroxy-Salicylate
5-Hydroxy-Salicylic acid
5-Hydroxysalicylate
Dihydroxybenzoicacid
Gentisinate
Hydroquinonecarboxylate
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GENTISIC ACID
ChEMBL ID
CHEMBL1461
Frequently Asked Questions
Is Gentisic Acid allowed in the EU?
Gentisic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gentisic Acid do in cosmetics?
Gentisic Acid functions as: Skin Conditioning, Antioxidant, Skin-Lightening, Antimicrobial. It is classified as a Antioxidant in our database. CAS number: 490-79-9.
Is Gentisic Acid used outside cosmetics?
Gentisic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Gentisic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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