Is gamma-Terpinene safe in cosmetics?
gamma-Terpinene has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
gamma-Terpinene
Also known as: 1,4-Cyclohexadiene, 1-methyl-4-isopropyl-, EINECS 202-794-6, FEMA No. 3559, 1-Methyl-4-isopropylcyclohexadiene-1,4, TERPINENE, ALPHA (+10 more)
INCI: GAMMA-TERPINENE
gamma-Terpinene (CAS 99-85-4) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; solvent; antimicrobial (monoterpene hydrocarbon). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 99-85-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
gamma-Terpinene is classified GHS Danger (H226, H304, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient; solvent; antimicrobial (monoterpene hydrocarbon)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
1-methyl-4-propan-2-ylcyclohexa-1,4-diene
InChIKey
YKFLAYDHMOASIY-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS; not listed in 21 CFR 700 (prohibited) or 21 CFR 250 (restricted)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for gamma-Terpinene.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3240 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
BRIN Brazil/India Cosmetics
India: Restricted
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (3)
JECFA Number
1340
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
gamma-TERPINENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
p-MENTHA-1,4-DIENE | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/64 | FAS 54-JECFA 63/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for gamma-Terpinene.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
eu_cosing_listed
Known Synonyms
1,4-Cyclohexadiene, 1-methyl-4-isopropyl-
EINECS 202-794-6
FEMA No. 3559
1-Methyl-4-isopropylcyclohexadiene-1,4
TERPINENE, ALPHA
UNII-4YGF4PQP49
1,4-p-Menthadiene
1-Isopropyl-4-methylcyclohexa-1,4-diene
1-Methyl-4-(propan-2-yl)cyclohexa-1,4-diene
1-isopropyl-4-methyl-cyclohexa-1,4-diene
1-methyl-4-propan-2-yl-cyclohexa-1,4-diene
1-methyl-4-propan-2-ylcyclohexa-1,4-diene
Terpinene
gamma Terpinene
gamma-Terpinen
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; emissions; Europe; nondetect; Other direct contact consumer goods
Europe; Personal care; restricted
inert_ingredient; non_food_use; Pesticides
air; consumer_product; detected; emissions
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
air; detected; emissions; Personal care
air; Cleaning products and household care - air freshener; detected; emissions
air; Cleaning products and household care; detected; emissions
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
SCIL (9/2019)
air; detected; emissions; Personal care
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
air; detected; emissions; Personal care
IFRA Transparency
air; detected; emissions; Europe; Vehicle - car interior
detected; Europe; Personal care - sexual wellness
air; detected; emissions; Europe; Vehicle - car interior
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GAMMA-TERPINENE
ChEMBL ID
CHEMBL449693
Frequently Asked Questions
Is gamma-Terpinene allowed in the EU?
gamma-Terpinene EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does gamma-Terpinene do in cosmetics?
gamma-Terpinene functions as: Fragrance ingredient; solvent; antimicrobial (monoterpene hydrocarbon). It is classified as a cosmetic ingredient in our database. CAS number: 99-85-4.
Is gamma-Terpinene used outside cosmetics?
gamma-Terpinene also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does gamma-Terpinene have different safety status in cosmetics vs industrial chemicals?
gamma-Terpinene is classified GHS Danger (H226, H304, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check gamma-Terpinene compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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