What is the NOAEL for Gamma-Terpinene?
Gamma-Terpinene has 9 NOAEL studies in the database. The lowest reported value is 2.939 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Gamma-Terpinene
Also known as: 1,4-Cyclohexadiene, 1-methyl-4-isopropyl-, EINECS 202-794-6, FEMA No. 3559, 1-Methyl-4-isopropylcyclohexadiene-1,4, TERPINENE, ALPHA (+10 more)
CAS 99-85-4
Gamma-Terpinene (CAS 99-85-4) is a chemical substance. Key regulatory status: REACH registered, 20 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
Cross-Vertical Regulatory Divergence
Gamma-Terpinene is classified GHS Danger (H226, H304, H411) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
9
SOURCE
chemical inventory jurisdictions
Regulatory lists
20
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
21 fields
Name
Gamma-Terpinene
CAS Number
99-85-4
DTXSID
DTXSID6041210
Molecular Formula
C10H16
InChI Key
YKFLAYDHMOASIY-UHFFFAOYSA-N
Monoisotopic Mass
136.125201
Synonyms
1,4-Cyclohexadiene, 1-methyl-4-isopropyl-EINECS 202-794-6FEMA No. 35591-Methyl-4-isopropylcyclohexadiene-1,4TERPINENE, ALPHAUNII-4YGF4PQP491,4-p-Menthadiene1-Isopropyl-4-methylcyclohexa-1,4-diene1-Methyl-4-(propan-2-yl)cyclohexa-1,4-diene1-isopropyl-4-methyl-cyclohexa-1,4-diene1-methyl-4-propan-2-yl-cyclohexa-1,4-diene1-methyl-4-propan-2-ylcyclohexa-1,4-diene
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
39 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
20 records
| List | Keyword | Source |
|---|---|---|
| air; emissions; Europe; nondetect; Other direct contact consumer goods | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care; restricted | European Commission | CosIng |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| air; consumer_product; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care - air freshener; detected; emissions | Elsevier | CPCat |
| air; Cleaning products and household care; detected; emissions | Elsevier | CPCat |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| air; Cleaning products and household care - laundry and fabric treatment; detected; emissions | Elsevier | CPCat |
| air; detected; emissions; Personal care | Elsevier | CPCat |
| IFRA Transparency | IFRA | IFRA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| air; detected; emissions; Europe; Vehicle - car interior | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
| detected; Europe; Personal care - sexual wellness | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 9 of 9 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.939 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 4YGF4PQP49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4YGF4PQP49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4YGF4PQP49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 4YGF4PQP49 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3240 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 9 of 9 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | p-mentha-1,4-diene | 202-794-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
GAMMA-TERPINENE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Gamma-Terpinene?
Gamma-Terpinene appears on 14 regulatory/inventory lists including air; emissions; Europe; nondetect; Other direct contact consumer goods, Europe; Personal care; restricted, inert_ingredient; non_food_use; Pesticides, and 11 more. Source: EPA CPDat.
Is Gamma-Terpinene used in cosmetics?
Yes, Gamma-Terpinene is also indexed as a cosmetic ingredient under the name gamma-Terpinene. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Gamma-Terpinene come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does Gamma-Terpinene have different safety status in cosmetics vs industrial chemicals?
Gamma-Terpinene is classified GHS Danger (H226, H304, H411) in the chemicals database but is allowed in EU cosmetics.
Is Gamma-Terpinene used outside industrial chemicals?
Gamma-Terpinene also appears in cosmetics, pharmaceutical, cannabis databases.