Is Gamma-Linolenic Acid safe in cosmetics?
Gamma-Linolenic Acid has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Gamma-Linolenic Acid
Also known as: Acide gamolenique, Acido gamolenico, Acidum gamolenicum, UNII-78YC2MAX4O, (6,9,12)-linolenate (+15 more)
INCI: GAMMA-LINOLENIC ACID
Gamma-Linolenic Acid (CAS 506-26-3) is a cosmetic cosmetic ingredient functioning as Emollient, Antioxidant, Skin Conditioning, Anti-inflammatory. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 506-26-3 →
Auto-generated CPSR Part A draft with source citations
Function
Emollient, Antioxidant, Skin Conditioning, Anti-inflammatory
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(6Z,9Z,12Z)-octadeca-6,9,12-trienoic acid
InChIKey
VZCCETWTMQHEPK-QNEBEIHSSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions; used freely as an emollient and essential fatty acid in cosmetics
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Gamma-Linolenic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Expert Verdict
Expert safety assessment and concern-level summary for Gamma-Linolenic Acid.
Regulatory Flags
essential-fatty-acid
omega-6
barrier-repair
anti-inflammatory
emollient
Known Synonyms
Acide gamolenique
Acido gamolenico
Acidum gamolenicum
UNII-78YC2MAX4O
(6,9,12)-linolenate
(6,9,12)-linolenic acid
(6Z,9Z,12Z)-Octadecatrienoate
(6Z,9Z,12Z)-Octadecatrienoic acid
(Z,Z,Z)-6,9,12-Octadecatrienoate
(Z,Z,Z)-6,9,12-octadecatrienoic acid
18:3 (n-6)
6(Z),9(Z),12(Z)-Octadecatrienoate
6,9,12-All-cis-Octadecatrienoate
6,9,12-Octadecatrienoate
6-cis,9-cis,12-cis-octadecatrienoic acid
6Z,9Z,12Z-Octadecatrienoate
6Z,9Z,12Z-Octadecatrienoic acid
All-cis-6,9,12-octadecatrienoate
C18:3 (n-6)
C18:3, n-6,9,12 all-cis
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GAMOLENIC ACID
ChEMBL ID
CHEMBL464982
Max Phase
3
Frequently Asked Questions
Is Gamma-Linolenic Acid allowed in the EU?
Gamma-Linolenic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gamma-Linolenic Acid do in cosmetics?
Gamma-Linolenic Acid functions as: Emollient, Antioxidant, Skin Conditioning, Anti-inflammatory. It is classified as a cosmetic ingredient in our database. CAS number: 506-26-3.
Is Gamma-Linolenic Acid used outside cosmetics?
Gamma-Linolenic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Gamma-Linolenic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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