Is Eicosapentaenoic Acid safe in cosmetics?
Eicosapentaenoic Acid has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Eicosapentaenoic Acid
INCI: EICOSAPENTAENOIC ACID
Eicosapentaenoic Acid (CAS 10417-94-4) is a cosmetic cosmetic ingredient functioning as Skin Conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 10417-94-4 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(5Z,8Z,11Z,14Z,17Z)-icosa-5,8,11,14,17-pentaenoic acid
InChIKey
JAZBEHYOTPTENJ-JLNKQSITSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as food substance; no specific FDA cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Eicosapentaenoic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Eicosapentaenoic Acid.
Regulatory Flags
omega-3
polyunsaturated-fatty-acid
anti-inflammatory
skin-conditioning
oxidation-sensitive
marine-derived
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; Personal care; Substances in PCP - Canada (4/2014)
pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ICOSAPENT
ChEMBL ID
CHEMBL460026
Max Phase
3
Adverse Event Associations
1992
Frequently Asked Questions
Is Eicosapentaenoic Acid allowed in the EU?
Eicosapentaenoic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Eicosapentaenoic Acid do in cosmetics?
Eicosapentaenoic Acid functions as: Skin Conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 10417-94-4.
Is Eicosapentaenoic Acid used outside cosmetics?
Eicosapentaenoic Acid also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Eicosapentaenoic Acid compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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