Is ARACHIDONIC ACID safe in cosmetics?
ARACHIDONIC ACID has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Cosmetic Ingredient
ARACHIDONIC ACID
Also known as: 5,8,11,14-Eicosatetraenoic acid, (5Z,8Z,11Z,14Z)-, (all-Z)-5,8,11,14-Eicosatetraenoic acid, 5,8,11,14-all-cis-Eicosatetraenoic acid, 5,8,11,14-Eicosatetraenoic acid, (all-Z)-, 5-cis,8-cis,11-cis,14-cis-Eicosatetraenoic acid (+15 more)
ARACHIDONIC ACID (CAS 506-32-1) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Skin Conditioning - Emollient. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 506-32-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Skin Conditioning - Emollient
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid
InChIKey
YZXBAPSDXZZRGB-DOFZRALJSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
CIR: UNS - IJT 34(Suppl.2):5-69, 2015
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "506-32-1", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "3", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "5-15", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "barrier-repair, anti-inflammatory", "mechanism_of_action": "Lipid barrier restoration, TEWL reduction, emollient", "target_skin_layer": "stratum corneum", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "…
comedogenicity_detail
{"comedogenicity_rating": "1", "irritancy_rating": "1", "skin_type_suitability": "all,combination,normal", "acne_safe": "yes", "source": "Biochemical studies"}
uv_stability
{"uv_stable": "partially", "uv_degradation_rate": "moderate", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "35", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_u…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for ARACHIDONIC ACID.
Regulatory Flags
cosing-sourced
eu-permitted
skin-conditioning
emollient
needs-enrichment
Known Synonyms
5,8,11,14-Eicosatetraenoic acid, (5Z,8Z,11Z,14Z)-
(all-Z)-5,8,11,14-Eicosatetraenoic acid
5,8,11,14-all-cis-Eicosatetraenoic acid
5,8,11,14-Eicosatetraenoic acid, (all-Z)-
5-cis,8-cis,11-cis,14-cis-Eicosatetraenoic acid
5Z,8Z,11Z,14Z-Eicosatetraenoic acid
acide icosa-5,8,11,14-tetraenoique
acido icosa-5,8,11,14-tetraenoico
all-cis-5,8,11,14-Eicosatetraenoic acid
cis-Δ5,8,11,14-Eicosatetraenoic acid
icosa-5,8,11,14-tetraenoic acid
Icosa-5,8,11,14-tetraensaure
AA
arachidonate
Immunocytophyte
ARA
EINECS 208-033-4
(5Z,8Z,11Z,14Z)-5,8,11,14-Eikosatetraensaeure
UNII-27YG812J1I
(5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoic acid
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ARACHIDONIC ACID
ChEMBL ID
CHEMBL15594
Max Phase
-1
Adverse Event Associations
10
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Arachidonic Acid (ArA)
Food Category
sports_nutrition
Frequently Asked Questions
Is ARACHIDONIC ACID allowed in the EU?
ARACHIDONIC ACID EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does ARACHIDONIC ACID do in cosmetics?
ARACHIDONIC ACID functions as: Skin Conditioning, Skin Conditioning - Emollient. It is classified as a cosmetic ingredient in our database. CAS number: 506-32-1.
Is ARACHIDONIC ACID used outside cosmetics?
ARACHIDONIC ACID also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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