Is gamma-Dodecalactone safe in cosmetics?
gamma-Dodecalactone has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
gamma-Dodecalactone
Also known as: 2(3H)-Furanone, dihydro-5-octyl-, Dodecanoic acid, 4-hydroxy-, γ-lactone, (RS)-γ-Dodecalactone, (±)-4-n-Octylbutyrolactone, 4-Hydroxydodecanoic acid γ-lactone (+15 more)
INCI: GAMMA-DODECALACTONE
gamma-Dodecalactone (CAS 2305-05-7) is a cosmetic cosmetic ingredient functioning as Fragrance, masking agent. NOAEL 750 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 2305-05-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, masking agent
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
5-octyloxolan-2-one
InChIKey
WGPCZPLRVAWXPW-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA 2400; FDA GRAS for food use
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for gamma-Dodecalactone.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for gamma-Dodecalactone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 7776 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "2305-05-7", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.14", "ifra_max_use_level_category_4_pct": "2.2", "ifra_max_use_level_category_7_pct": "0.32", "ifra_max_use_level_category_11_pct": "0.065", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_p…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
gamma-DODECALACTONE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/42 | FAS 40-JECFA 49/231
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for gamma-Dodecalactone.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
2(3H)-Furanone, dihydro-5-octyl-
Dodecanoic acid, 4-hydroxy-, γ-lactone
(RS)-γ-Dodecalactone
(±)-4-n-Octylbutyrolactone
4-Hydroxydodecanoic acid γ-lactone
5-Octyltetrahydro-2-furanone
γ-Dodecalactone
γ-Dodecanolactone
γ-Laurolactone
γ-Octyl-γ-butyrolactone
Dihydro-5-octylfuran-2(3H)-one
dihydro-5-octylfuranne-2(3H)-one
Dihydro-5-octylfuran-2(3H)-on
dihidro-5-octilfuran-2(3H)-ona
DODECALACTONE
DODECALACTONE-γ
2(3h)-furanona, dihidro-5-octil-
(±)-γ-Dodecalactone
Dihydro-5-octyl-2(3H)-furanone
Dodecanoic acid, 4-hydroxy-, gamma-lactone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL195215
Frequently Asked Questions
Is gamma-Dodecalactone allowed in the EU?
gamma-Dodecalactone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does gamma-Dodecalactone do in cosmetics?
gamma-Dodecalactone functions as: Fragrance, masking agent. It is classified as a cosmetic ingredient in our database. CAS number: 2305-05-7.
Is gamma-Dodecalactone used outside cosmetics?
gamma-Dodecalactone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check gamma-Dodecalactone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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