What is the NOAEL for Gamma-Dodecalactone?
Gamma-Dodecalactone has 10 NOAEL studies in the database. The lowest reported value is 8.82 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Gamma-Dodecalactone
Also known as: 2(3H)-Furanone, dihydro-5-octyl-, Dodecanoic acid, 4-hydroxy-, γ-lactone, (RS)-γ-Dodecalactone, (±)-4-n-Octylbutyrolactone, 4-Hydroxydodecanoic acid γ-lactone (+15 more)
CAS 2305-05-7
Gamma-Dodecalactone (CAS 2305-05-7) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Gamma-Dodecalactone
CAS Number
2305-05-7
DTXSID
DTXSID7047190
Molecular Formula
C12H22O2
InChI Key
WGPCZPLRVAWXPW-UHFFFAOYSA-N
Monoisotopic Mass
198.16198
Synonyms
2(3H)-Furanone, dihydro-5-octyl-Dodecanoic acid, 4-hydroxy-, γ-lactone(RS)-γ-Dodecalactone(±)-4-n-Octylbutyrolactone4-Hydroxydodecanoic acid γ-lactone5-Octyltetrahydro-2-furanoneγ-Dodecalactoneγ-Dodecanolactoneγ-Laurolactoneγ-Octyl-γ-butyrolactoneDihydro-5-octylfuran-2(3H)-onedihydro-5-octylfuranne-2(3H)-one
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
18 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =8.82 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| YX9N4581LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YX9N4581LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YX9N4581LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| YX9N4581LU | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 7776 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >2000 | mg/kg bw/day | LEL | dermal | Rat | ToxValDB_ECHA_IUCLID |
| ~750 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 10 of 10 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Dihydro-5-octylfuran-2(3H)-one | 218-971-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL195215
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Gamma-Dodecalactone?
Gamma-Dodecalactone appears on 3 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), consumer_product. Source: EPA CPDat.
Is Gamma-Dodecalactone used in cosmetics?
Yes, Gamma-Dodecalactone is also indexed as a cosmetic ingredient under the name gamma-Dodecalactone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Gamma-Dodecalactone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Gamma-Dodecalactone used outside industrial chemicals?
Gamma-Dodecalactone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.