Is Gamma-Cyclodextrin safe in cosmetics?
Gamma-Cyclodextrin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Gamma-Cyclodextrin
Also known as: gamma-Dextrin, Dexy Pearl gamma-100, EINECS 241-482-4, UNII-KZJ0BYZ5VA, Gamma cyclodextrin (+1 more)
INCI: GAMMA-CYCLODEXTRIN
Gamma-Cyclodextrin (CAS 17465-86-0) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Encapsulating Agent, Masking. Reported NOAEL =120 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 17465-86-0 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Encapsulating Agent, Masking
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36S,38R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R,50R,51R,52R,53R,54R,55R,56R)-5,10,15,20,25,30,35,40-octakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34,37,39-hexadecaoxanonacyclo[36.2.2.23,6.28,11.213,16.218,21.223,26.228,31.233,36]hexapentacontane-41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56-hexadecol
InChIKey
GDSRMADSINPKSL-HSEONFRVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
FDA recognizes cyclodextrins as safe; gamma-cyclodextrin used as GRAS food ingredient and cosmetic excipient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Gamma-Cyclodextrin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Gamma-Cyclodextrin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =120 mg/kg bw/day | injection | Rat | subchronic | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
deodorant
{"cas_number": "17465-86-0", "ingredient_class": "odor_absorber", "mechanism_of_action": "odor_absorption", "antiperspirant_efficacy_sweat_reduction_pct": "0", "deodorant_efficacy_hours": "8-16", "odor_reduction_pct": "50-75", "bacteriostatic": "no", "bactericidal": "no", "microbiome_impact": "neutral", "axillary_microbiome_effect": "minimal", "sweat_absorption_capacity": "low", "odor_molecule_bin…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Carcinogen Classification
No indication of carcinogenicity to humans (not listed by IARC).
Source: Toxin and Toxin Target Database (T3DB)
Regulatory (3)
JECFA Evaluation
gamma-CD | 1999 | NOT SPECIFIED | TRS 896-JECFA 53/26 | FAS 44-JECFA 53/101
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
CYCLOOCTAAMYLOSE | 1999 | NOT SPECIFIED | TRS 896-JECFA 53/26 | FAS 44-JECFA 53/101
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
gamma-CYCLODEXTRIN | 1999 | NOT SPECIFIED | TRS 896-JECFA 53/26 | FAS 44-JECFA 53/101
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Expert Verdict
Expert safety assessment and concern-level summary for Gamma-Cyclodextrin.
Regulatory Flags
encapsulation
fragrance-stabilizer
delivery-system
polysaccharide
non-irritating
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Gamma-Cyclodextrin by CAS number or substance name.
Studies
1
Lowest NOAEL
120 mg/kg bw/day
Highest NOAEL
120 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
gamma-Dextrin
Dexy Pearl gamma-100
EINECS 241-482-4
UNII-KZJ0BYZ5VA
Gamma cyclodextrin
gamma-CD
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
GAMMA-CYCLODEXTRIN
ChEMBL ID
CHEMBL3182126
Max Phase
-1
SOURCE
EFSA / FDA GRAS
fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Gamma cyclodextrin
FDA GRAS
FDA has no questions
GRN
46
Use in bread spreads, frozen dairy desserts, ready-to-eat dairy desserts, desserts prepared from dry mixes, fruit fillings, cheese and cream fillings, and chewing gum as a stabilizer, emulsifier, carrier and formulation aid at varying levels
View full food safety profile →Frequently Asked Questions
Is Gamma-Cyclodextrin allowed in the EU?
Gamma-Cyclodextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Gamma-Cyclodextrin do in cosmetics?
Gamma-Cyclodextrin functions as: Skin Conditioning, Encapsulating Agent, Masking. It is classified as a cosmetic ingredient in our database. CAS number: 17465-86-0.
What is the NOAEL for Gamma-Cyclodextrin?
The NOAEL (No Observed Adverse Effect Level) for Gamma-Cyclodextrin is =120 mg/kg bw/day based on a subchronic study via injection route in Rat. Source: ToxValDB_ECHA_IUCLID.
Is Gamma-Cyclodextrin used outside cosmetics?
Gamma-Cyclodextrin also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Gamma-Cyclodextrin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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