Is Cyclodextrin safe in cosmetics?
Cyclodextrin has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Cyclodextrin
Also known as: 2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv., B 100H, BW 7, BW 7 (polysaccharide), Stereoisomer of 5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol (+14 more)
INCI: CYCLODEXTRIN
Cyclodextrin (CAS 7585-39-9) is a cosmetic cosmetic ingredient functioning as Absorbent, Carrier, Encapsulant, Solubilizer. Reported NOAEL =225 mg/kg bw/day in Mouse (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 7585-39-9 →
Auto-generated CPSR Part A draft with source citations
Function
Absorbent, Carrier, Encapsulant, Solubilizer
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
(1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
InChIKey
WHGYBXFWUBPSRW-FOUAGVGXSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
GRAS as food substance. No specific FDA cosmetic restrictions. Listed on TSCA inventory.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Cyclodextrin.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Cyclodextrin. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =225 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =400 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =975 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Dog | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =5000 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
4 property records from structured ingredient metadata.
pediatric_safety
{"safe_for_newborn_0_6m": "yes", "safe_for_infant_6_12m": "yes", "safe_for_toddler_1_3y": "yes", "safe_for_child_3_12y": "yes", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "5.0", "adult_max_concentration_pct": "5.0", "pediatric_dermal_absorption_factor": "minimal", "oral_ingestion_risk": "low", "diaper_area_safe": "yes", "pediatric_allergy_prevalence": "low", "banned_in_child…
self_tanning
{"cas_number": "7585-39-9", "ingredient_class": "other", "tanning_mechanism": "other", "color_development_onset_hours": "0.0", "full_color_development_hours": "0", "color_duration_days": "0", "DHA_concentration_if_applicable_pct": "0", "erythrulose_concentration_pct": "0", "pH_dependent_color": "no", "formaldehyde_release_concern": "no", "formaldehyde_release_ppm": "0", "AGE_formation_concern": "n…
sensory
{"silky": "powdery", "smooth, glides easily": "smooth, encapsulating", "dry-touch, non-greasy": "smooth, protected", "instant": "moderate", "low": "medium", "w/o": "o/w", "very-high": "moderate", "no": "no", "yes": "yes", "1.40": "1.56", "transparent": "opaque", "colorless": "white", "excellent": "fair", "light": "light", "synthetic": "biotechnology"}
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "no", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "0", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv": …
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Evaluation
CYCLODEXTRIN B | 1995 | 0-5 mg/kg bw | JECFA revised the previous temporary ADI (0-6 mg/kg bw) and allocated an ADI of 0-5 mg/kg bw for beta-cyclodextrin based on a NOEL of 1.25% in the diet (equal to 470 mg/kg bw/day) in a 1-year study in dogs and a safety factor of 100. | TRS 859-JECFA 44/28 | FAS 35-JECFA 44/257
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-CYCLODEXTRIN | 1995 | 0-5 mg/kg bw | JECFA revised the previous temporary ADI (0-6 mg/kg bw) and allocated an ADI of 0-5 mg/kg bw for beta-cyclodextrin based on a NOEL of 1.25% in the diet (equal to 470 mg/kg bw/day) in a 1-year study in dogs and a safety factor of 100. | TRS 859-JECFA 44/28 | FAS 35-JECFA 44/257
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
beta-SCHARDINGER DEXTRIN | 1995 | 0-5 mg/kg bw | JECFA revised the previous temporary ADI (0-6 mg/kg bw) and allocated an ADI of 0-5 mg/kg bw for beta-cyclodextrin based on a NOEL of 1.25% in the diet (equal to 470 mg/kg bw/day) in a 1-year study in dogs and a safety factor of 100. | TRS 859-JECFA 44/28 | FAS 35-JECFA 44/257
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
EU Food Improvement
Food additives
Source: EU Food Improvement Agents
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Processing aids not otherwise specified
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Cyclodextrin.
Regulatory Flags
cir-cleared
gras
low-dermal-absorption
encapsulant
well-characterized
epa_safer_alternative
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Cyclodextrin by CAS number or substance name.
Studies
5
Lowest NOAEL
225 mg/kg bw/day
Highest NOAEL
5000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2,4,7,9,12,14,17,19,22,24,27,29,32,34-Tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane, β-cyclodextrin deriv.
B 100H
BW 7
BW 7 (polysaccharide)
Stereoisomer of 5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,37,38,39,40,41,42,43,44,45,46,47,48,49-tetradecol
Dexipar β-100
Dexy Pearl 100
HP-β-CD
Kleptose STD
VTS 270
CYCLODEXTRIN, β-
betadex
.beta.-Cyclodextrin
beta-Dextrin
Dextrin, beta-cyclo
EINECS 231-493-2
Schardinger beta-dextrin
beta-Cycloheptaamylose
UNII-JV039JZZ3A
Chemical Function
Deodorizer
Processing aids not otherwise specified
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BETADEX
ChEMBL ID
CHEMBL415690
Max Phase
3
Adverse Event Associations
18
SOURCE
EFSA / FDA GRAS
food_additives + fda_gras_enriched
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
Beta-cyclodextrin
E Number
E459
ADI
5 mg/kg bw
FDA GRAS
FDA has no questions
GRN
74
Food Category
emulsifier
Use in baked goods prepared from dry mixes, breakfast cereal, chewing gum, gelatins and puddings, dry mix for soups, flavored coffee and tea, compressed candies, processed cheese products, flavored savory snacks and crackers, dry mix for beverages as a flavor...
View full food safety profile →Frequently Asked Questions
Is Cyclodextrin allowed in the EU?
Cyclodextrin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Cyclodextrin do in cosmetics?
Cyclodextrin functions as: Absorbent, Carrier, Encapsulant, Solubilizer. It is classified as a cosmetic ingredient in our database. CAS number: 7585-39-9.
What is the NOAEL for Cyclodextrin?
The NOAEL (No Observed Adverse Effect Level) for Cyclodextrin is =225 mg/kg bw/day based on a chronic study via oral route in Mouse. A total of 5 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Cyclodextrin used outside cosmetics?
Cyclodextrin also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Cyclodextrin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Amorphophallus Konjac Root Extract
Excellent
Same category
Film-forming agent and humectant deri...
Arabinogalactan
Excellent
Same category
Film former, emulsion stabilizer, hum...
Astragalus Gummifer Gum
Excellent
Same category
viscosity increasing agent-aqueous, b...
Cassia Angustifolia Seed Polysaccharide
Excellent
Same category
Skin conditioning agent; film-forming...
Dextran
Excellent
Same category
Binding, Viscosity Controlling
Galactoarabinan
Excellent
Same category
Film-forming agent, moisturizer, SPF ...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
2-O-Ethyl Ascorbic Acid
Excellent
Similar safety
Softener and conditioner
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
CYCLIC ADENOSINE DIPHOSPHATE RIBOSE
Good
Browse nearby
Hair Conditioning, Skin Conditioning,...
CYCLOHEXANE DIMETHANOL
Good
Browse nearby
Not Reported
CYCLOHEXYL METHACRYLATE
Good
Browse nearby
Film Forming
Is Cyclodextrin in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Cyclodextrin in your formulation.