What is the NOAEL for Ferric hexacyanoferrate (II)?
Ferric hexacyanoferrate (II) has 15 NOAEL studies in the database. The lowest reported value is TLE294X33A UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Ferric hexacyanoferrate (II)
Also known as: Prussian blue, CI 77510 Blue, Iron ferrocyanide (Fe4[Fe(CN)6]3), EC No.: 237-875-5, EINECS 237-875-5 (+12 more)
CAS 14038-43-8
Ferric hexacyanoferrate (II) (CAS 14038-43-8) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Ferric Ferrocyanide (Prussian Blue) →
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Ferric hexacyanoferrate (II)
CAS Number
14038-43-8
DTXSID
DTXSID9047756
Molecular Formula
18CN.7Fe
InChI Key
DCYOBGZUOMKFPA-UHFFFAOYSA-N
Monoisotopic Mass
859.599886
Synonyms
Prussian blueCI 77510 BlueIron ferrocyanide (Fe4[Fe(CN)6]3)EC No.: 237-875-5EINECS 237-875-5Iron hexacyanoferrateTetrairon(3+) tris(hexacyanoferrate(4-))Iron(3 ) hexacyanoferrate(4-) (4:3)Insoluble Prussian BlueUNII-TLE294X33ABerliner BlauFe4[Fe(CN)6]3
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
8 records
DyeAbrasive
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| TLE294X33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TLE294X33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TLE294X33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| TLE294X33A | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >=250 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2500 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =25 | mg/kg bw/day | NOAEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| =25 | mg/kg bw/day | NOAEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| =25 | mg/kg bw/day | NOAEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| =25 | mg/kg bw/day | NOAEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| <=2500 | mg/kg bw/day | NOEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| <=2500 | mg/kg bw/day | NOEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| <=2500 | mg/kg bw/day | NOEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| <=2500 | mg/kg bw/day | NOEL | oral: feed | rat (2207; male/female) | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Prussian blue | 237-875-5 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
Must be free from cyanide ions (purity condition)
Category
colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
prussian blue
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Frequently Asked Questions
What regulatory lists include Ferric hexacyanoferrate (II)?
Ferric hexacyanoferrate (II) appears on 4 regulatory/inventory lists including inert_ingredient; non_food_use; Pesticides, pharmaceutical, Personal care, and 1 more. Source: EPA CPDat.
Is Ferric hexacyanoferrate (II) used in cosmetics?
Yes, Ferric hexacyanoferrate (II) is also indexed as a cosmetic ingredient under the name Ferric Ferrocyanide (Prussian Blue). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Ferric hexacyanoferrate (II) come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Ferric hexacyanoferrate (II) used outside industrial chemicals?
Ferric hexacyanoferrate (II) also appears in cosmetics, pharmaceutical databases.