Is Eugenyl Acetate safe in cosmetics?
Eugenyl Acetate has a safety rating of "GOOD" in our database. EU status: prohibited. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Eugenyl Acetate
Also known as: 4-Allyl-2-methoxyphenyl acetate, Eugenol acetate, 2-Methoxy-4-(prop-2-en-1-yl)phenyl acetate, 2-Methoxy-4-(2-propenyl)phenyl acetate, Phenol, 4-allyl-2-methoxy-, acetate (+12 more)
INCI: EUGENYL ACETATE
Eugenyl Acetate (CAS 93-28-7) is a cosmetic cosmetic ingredient functioning as Fragrance / Masking. NOAEL 300 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 93-28-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Eugenyl Acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance / Masking
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2-methoxy-4-prop-2-enylphenyl) acetate
InChIKey
SCCDQYPEOIRVGX-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
permitted
US Notes
Permitted — no specific 21 CFR cosmetic restriction; FEMA GRAS for food flavoring
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Eugenyl Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Eugenyl Acetate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 1000 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Eugenyl Acetate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | 103 | 0 | 9448 | 9448 | non-sensitizer |
| HMT | - | 0 | 12960 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1531
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-ALLYL-2-METHOXYPHENYL ACETATE | 2005 | No safety concern at current levels of intake when used as a flavouring agent | TRS 934-JECFA 65/49 | FAS 56-JECFA 65
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
EUGENYL ACETATE | 2005 | No safety concern at current levels of intake when used as a flavouring agent | TRS 934-JECFA 65/49 | FAS 56-JECFA 65
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Eugenyl Acetate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Eugenyl Acetate by CAS number or substance name.
Studies
1
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
COSMOS_DB
Known Synonyms
4-Allyl-2-methoxyphenyl acetate
Eugenol acetate
2-Methoxy-4-(prop-2-en-1-yl)phenyl acetate
2-Methoxy-4-(2-propenyl)phenyl acetate
Phenol, 4-allyl-2-methoxy-, acetate
3-06-00-05029
Aceteugenol
1-Acetoxy-2-methoxy-4-allylbenzene
Acetyl eugenol
4-Allyl-2-methoxyphenol acetate
BRN 1964745
EINECS 202-235-6
1,3,4-Eugenol acetate
FEMA No. 2469
2-Methoxy-4-(2-propen-1-yl)phenyl acetate
NSC 1242
UNII-V9OSB376X8
Chemical Function
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
EUGENYL ACETATE
ChEMBL ID
CHEMBL108299
Frequently Asked Questions
Is Eugenyl Acetate allowed in the EU?
Eugenyl Acetate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Eugenyl Acetate do in cosmetics?
Eugenyl Acetate functions as: Fragrance / Masking. It is classified as a cosmetic ingredient in our database. CAS number: 93-28-7.
What is the NOAEL for Eugenyl Acetate?
The NOAEL (No Observed Adverse Effect Level) for Eugenyl Acetate is 1000 mg/kg bw/day based on a Subchronic study via oral route in rat. Source: COSMOS_DB.
Is Eugenyl Acetate used outside cosmetics?
Eugenyl Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Eugenyl Acetate have different safety status in cosmetics vs industrial chemicals?
Eugenyl Acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H302).
Compliance Tools
Check Eugenyl Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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