Is Ethylhexyl Methacrylate ⚠️ safe in cosmetics?
Ethylhexyl Methacrylate ⚠️ has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Ethylhexyl Methacrylate ⚠️
Also known as: 2-Propenoic acid, 2-methyl-, 2-ethylhexyl ester, 2-Ethylhexyl methacrylate, 4-02-00-01528, BRN 1769420, EINECS 211-708-6 (+4 more)
INCI: ETHYLHEXYL METHACRYLATE
Ethylhexyl Methacrylate ⚠️ (CAS 688-84-6) is a cosmetic cosmetic ingredient functioning as Film former (primarily nail enhancement products). NOAEL 30 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 688-84-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethylhexyl Methacrylate ⚠️ is classified GHS CMR hazard (H315, H317, H319, H335, H412, H227, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Film former (primarily nail enhancement products)
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-ethylhexyl 2-methylprop-2-enoate
InChIKey
WDQMWEYDKDCEHT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — CIR: safe as used in nail products only when accompanied by directions to avoid skin contact
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylhexyl Methacrylate ⚠️.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Ethylhexyl Methacrylate ⚠️. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =30 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rabbit | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =120 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =360 mg/kg bw/day | oral | Rat | repeat dose other | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes and skin.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethylhexyl Methacrylate ⚠️ across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1289
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
The substance irritates the eyes and the skin.
Source: Hazardous Substances Data Bank (HSDB)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Film former
Regulatory List Membership (1)
FDA Indirect Food Contact Additives
Expert Verdict
Expert safety assessment and concern-level summary for Ethylhexyl Methacrylate ⚠️.
Regulatory Flags
potential-allergen
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethylhexyl Methacrylate ⚠️ by CAS number or substance name.
Studies
5
Lowest NOAEL
30 mg/kg bw/day
Highest NOAEL
360 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Propenoic acid, 2-methyl-, 2-ethylhexyl ester
2-Ethylhexyl methacrylate
4-02-00-01528
BRN 1769420
EINECS 211-708-6
2-Ethylhexyl methacryate
2-Ethyl-1-hexyl methacrylate
Methacrylate, 2-ethylisohexy
UNII-8Q7XLQ325N
Chemical Function
Film former
Regulatory Lists
Indirect additives food contact (10/2018)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1871010
Frequently Asked Questions
Is Ethylhexyl Methacrylate ⚠️ allowed in the EU?
Ethylhexyl Methacrylate ⚠️ EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylhexyl Methacrylate ⚠️ do in cosmetics?
Ethylhexyl Methacrylate ⚠️ functions as: Film former (primarily nail enhancement products). It is classified as a cosmetic ingredient in our database. CAS number: 688-84-6.
What is the NOAEL for Ethylhexyl Methacrylate ⚠️?
The NOAEL (No Observed Adverse Effect Level) for Ethylhexyl Methacrylate ⚠️ is =30 mg/kg bw/day based on a subchronic study via oral route in Rat. A total of 5 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Ethylhexyl Methacrylate ⚠️ used outside cosmetics?
Ethylhexyl Methacrylate ⚠️ also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethylhexyl Methacrylate ⚠️ have different safety status in cosmetics vs industrial chemicals?
Ethylhexyl Methacrylate ⚠️ is classified GHS CMR hazard (H315, H317, H319, H335, H412, H227, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Ethylhexyl Methacrylate ⚠️ compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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