What is the NOAEL for 2-Ethylhexyl 2-methyl-2-propenoate?
2-Ethylhexyl 2-methyl-2-propenoate has 11 NOAEL studies in the database. The lowest reported value is 2.5 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Ethylhexyl 2-methyl-2-propenoate
Also known as: 2-Propenoic acid, 2-methyl-, 2-ethylhexyl ester, 2-Ethylhexyl methacrylate, 4-02-00-01528, BRN 1769420, EINECS 211-708-6 (+4 more)
CAS 688-84-6
2-Ethylhexyl 2-methyl-2-propenoate (CAS 688-84-6) is a chemical substance. Key regulatory status: REACH registered, 1 regulatory/inventory list, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
View cosmetic safety profile for Ethylhexyl Methacrylate ⚠️ →
Cross-Vertical Regulatory Divergence
2-Ethylhexyl 2-methyl-2-propenoate is classified GHS CMR hazard (H315, H317, H319, H335, H412, H227, H361, H401) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
1
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
2-Ethylhexyl 2-methyl-2-propenoate
CAS Number
688-84-6
DTXSID
DTXSID3027293
Molecular Formula
C12H22O2
InChI Key
WDQMWEYDKDCEHT-UHFFFAOYSA-N
Monoisotopic Mass
198.16198
Synonyms
2-Propenoic acid, 2-methyl-, 2-ethylhexyl ester2-Ethylhexyl methacrylate4-02-00-01528BRN 1769420EINECS 211-708-62-Ethylhexyl methacryate2-Ethyl-1-hexyl methacrylateMethacrylate, 2-ethylisohexyUNII-8Q7XLQ325N
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
SOURCE
ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| Short-term Effects | The substance is irritating to the eyes and skin. |
| Routes of Exposure | The substance can be absorbed into the body by inhalation of its aerosol. |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
Film former
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
1 records
| List | Keyword | Source |
|---|---|---|
| Indirect additives food contact (10/2018) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =2.5 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 8Q7XLQ325N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Q7XLQ325N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Q7XLQ325N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8Q7XLQ325N | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >2000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =30 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =100 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =120 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =300 | mg/kg bw/day | NOAEL | oral | Rabbit | ToxValDB_ECHA_IUCLID |
| =360 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2-ethylhexyl methacrylate | 211-708-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Cosmetic Ingredient
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1871010
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include 2-Ethylhexyl 2-methyl-2-propenoate?
2-Ethylhexyl 2-methyl-2-propenoate appears on 1 regulatory/inventory list including Indirect additives food contact (10/2018). Source: EPA CPDat.
Is 2-Ethylhexyl 2-methyl-2-propenoate used in cosmetics?
Yes, 2-Ethylhexyl 2-methyl-2-propenoate is also indexed as a cosmetic ingredient under the name Ethylhexyl Methacrylate ⚠️. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Ethylhexyl 2-methyl-2-propenoate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 2-Ethylhexyl 2-methyl-2-propenoate have different safety status in cosmetics vs industrial chemicals?
2-Ethylhexyl 2-methyl-2-propenoate is classified GHS CMR hazard (H315, H317, H319, H335, H412, H227, H361, H401) in the chemicals database but is allowed in EU cosmetics.
Is 2-Ethylhexyl 2-methyl-2-propenoate used outside industrial chemicals?
2-Ethylhexyl 2-methyl-2-propenoate also appears in cosmetics, pharmaceutical databases.