Is Ethylene Brassylate (Macrocycle) safe in cosmetics?
Ethylene Brassylate (Macrocycle) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Ethylene Brassylate (Macrocycle)
Also known as: 4-19-00-01936, BRN 0212344, Cyclo-1,13-ethylenedioxytridecan-1,13-dione, EINECS 203-347-8, Ethyl brassylate (+5 more)
INCI: ETHYLENE BRASSYLATE
Ethylene Brassylate (Macrocycle) (CAS 105-95-3) is a cosmetic cosmetic ingredient functioning as Fragrance, Tonic (creates a pleasant feeling on skin/hair). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety, pharmaceutical, and food safety data.
View industrial chemical safety profile for CAS 105-95-3 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Tonic (creates a pleasant feeling on skin/hair)
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
1,4-dioxacycloheptadecane-5,17-dione
InChIKey
XRHCAGNSDHCHFJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — no FDA restrictions; FEMA GRAS #3543; IFRA unrestricted status globally as of 2025
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethylene Brassylate (Macrocycle).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethylene Brassylate (Macrocycle) across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
12992 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [153] Kligman AM (1973): Report to RIFM, 13 July, unpublished.
HRIPT Human Patch Test Studies
5 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 19440 | - | - |
| HRIPT | - | 0 | 12992.13 | - | - |
| HRIPT | - | 0 | 12992.13 | - | - |
| HRIPT | - | 0 | 12992.13 | - | - |
| HRIPT | - | 0 | 12992.13 | - | - |
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: fragrance
Receptor targets: ERα (not estrogenically active per E-screen)
LOEC: N/A (inactive)
EU status: allowed
no significant ER activity
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance
{"cas_number": "105-95-3", "ingredient_class": "synthetic_musk", "chemical_class": "macrocyclic", "odor_family": "musk", "odor_description": "Musk, fatty, waxy, powdery", "odor_strength": "medium", "odor_tenacity_hours": "200.0", "top_note": "no", "heart_note": "no", "base_note": "yes", "blending_factor_1_10": "7.0", "threshold_of_detection_ppb": "50.0", "molecular_weight_Da": "270.41", "boiling_p…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (3)
JECFA Number
626
Source: WHO/JECFA
JECFA Evaluation
CYCLO-1,13-ETHYLENEDIOXYTRIDECAN-1,13-DIONE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: WHO/JECFA
JECFA Evaluation
ETHYLENE BRASSYLATE | 1999 | No safety concern at current levels of intake when used as a flavouring agent | TRS 896-JECFA 53/67 | FAS 44-JECFA 53/229
Source: WHO/JECFA
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethylene Brassylate (Macrocycle).
Regulatory Flags
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
Known Synonyms
4-19-00-01936
BRN 0212344
Cyclo-1,13-ethylenedioxytridecan-1,13-dione
EINECS 203-347-8
Ethyl brassylate
Ethylene glycol brassylate, cyclic diester
Ethylene glycol, cyclic tridecanedioate
FEMA No. 3543
UNII-9A87HC7ROD
Musk T
Chemical Function
Fragrance
Deodorizer
Humectant
Regulatory Lists
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
SCIL (9/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical and food safety data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2059298
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
ETHYL BRASSYLATE
Food Category
flavoring
Frequently Asked Questions
Is Ethylene Brassylate (Macrocycle) allowed in the EU?
Ethylene Brassylate (Macrocycle) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethylene Brassylate (Macrocycle) do in cosmetics?
Ethylene Brassylate (Macrocycle) functions as: Fragrance, Tonic (creates a pleasant feeling on skin/hair). It is classified as a cosmetic ingredient in our database. CAS number: 105-95-3.
Is Ethylene Brassylate (Macrocycle) used outside cosmetics?
Ethylene Brassylate (Macrocycle) also appears in industrial chemical safety, pharmaceutical, and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethylene Brassylate (Macrocycle) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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