Is Ethyl Propionate safe in cosmetics?
Ethyl Propionate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Ethyl Propionate
Also known as: Propanoic acid, Ethyl ester, 4-02-00-00705, BRN 0506287, EINECS 203-291-4, FEMA No. 2456 (+7 more)
Ethyl Propionate (CAS 105-37-3) is a cosmetic cosmetic ingredient functioning as Flavouring and nutrient; Fragrance; Solvent. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 105-37-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Ethyl Propionate is classified GHS Danger (H225, H315, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Flavouring and nutrient; Fragrance; Solvent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
ethyl propanoate
InChIKey
FKRCODPIKNYEAC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Propionate.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Propionate across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Flammable
Hazard Class and Category
Flam. Liq. 2
Hazard Statements
- H225 Highly flammable liquid and vapour
Inserted via ATP: CLP00
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
A skin and eye irritant.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
28
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ETHYL PROPIONATE | 1996 | No safety concern at current levels of intake when used as a flavouring agent | TRS 868-JECFA 46/21 | See TRS 868-JECFA 46/64
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Propionate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
Propanoic acid, Ethyl ester
4-02-00-00705
BRN 0506287
EINECS 203-291-4
FEMA No. 2456
Ethylester kyseliny propionove
UNII-AT9K8FY49U
Ethyl ester of propanoic acid
Ethyl n-propionate
Ethylpropionate
FEMA 2456
propionic acid ethyl ester
Chemical Function
Fragrance
Solvent
Flavouring and nutrient
Regulatory Lists
inert_ingredient; non_food_use; Pesticides
Australia; Food and drug - smoking-related products
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ETHYL PROPIONATE
ChEMBL ID
CHEMBL44115
Frequently Asked Questions
Is Ethyl Propionate allowed in the EU?
Ethyl Propionate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Propionate do in cosmetics?
Ethyl Propionate functions as: Flavouring and nutrient; Fragrance; Solvent. It is classified as a cosmetic ingredient in our database. CAS number: 105-37-3.
Is Ethyl Propionate used outside cosmetics?
Ethyl Propionate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Ethyl Propionate have different safety status in cosmetics vs industrial chemicals?
Ethyl Propionate is classified GHS Danger (H225, H315, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Ethyl Propionate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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