Is Ethyl Methylphenylglycidate safe in cosmetics?
Ethyl Methylphenylglycidate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted. 5 toxicological study endpoint(s) are available in our database.
Ethyl Methylphenylglycidate
Also known as: Ethyl-3-methyl-3-phenylglycidate, 3-Methyl-3-phenylglycidic acid, ethyl ester, 2-Oxiranecarboxylic acid, 3-methyl-3-phenyl-, ethyl ester, C-16 aldehyde, 5-18-06-00385 (+14 more)
INCI: ETHYL METHYLPHENYLGLYCIDATE
Ethyl Methylphenylglycidate (CAS 77-83-8) is a cosmetic cosmetic ingredient functioning as Fragrance (also known as Strawberry Aldehyde / Aldehyde C-16). NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 77-83-8 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance (also known as Strawberry Aldehyde / Aldehyde C-16)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
ethyl 3-methyl-3-phenyloxirane-2-carboxylate
InChIKey
LQKRYVGRPXFFAV-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — no specific CFR restriction for cosmetic use; also GRAS as a flavoring substance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Ethyl Methylphenylglycidate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
5 study endpoints found for Ethyl Methylphenylglycidate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 50 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 125 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 195 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | 250 mg/kg bw/day | oral | rat | Chronic | COSMOS_DB |
| NOAEL | =39 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Ethyl Methylphenylglycidate across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 648 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (2)
JECFA Number
1577
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL-3-PHENYLGLYCIDIC ACID, 3- ETHYL ESTER | 2005 | 0-0.5 mg/kg bw (1984) | The ADI established at the twenty-eighth meeting was maintained. | TRS 934-JECFA 65/82 | FAS 56-JECFA 65
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Viscosity modifier
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Ethyl Methylphenylglycidate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Ethyl Methylphenylglycidate by CAS number or substance name.
Studies
5
Lowest NOAEL
39 mg/kg bw/day
Highest NOAEL
250 mg/kg bw/day
ToxValDB_ECHA_IUCLID
COSMOS_DB
Known Synonyms
Ethyl-3-methyl-3-phenylglycidate
3-Methyl-3-phenylglycidic acid, ethyl ester
2-Oxiranecarboxylic acid, 3-methyl-3-phenyl-, ethyl ester
C-16 aldehyde
5-18-06-00385
BRN 0012299
Butanoic acid, 2,3-epoxy-3-phenyl-, ethyl ester
EINECS 201-061-8
alpha,beta-Epoxy-beta-methylhydrocinnamic acid, ethyl ester
2,3-Epoxy-3-phenylbutyric acid, ethyl ester
Ethyl alpha,beta-epoxy-beta-methylhydrocinnamate
Ethyl alpha,beta-epoxy-beta-methylphenylpropionate
Ethyl 2,3-epoxy-2-methyl-3-phenylpropionate
Ethyl 2,3-epoxy-3-methyl-3-phenylpropionate
Ethyl ester of 2,3-epoxy-3-phenylbutanoic acid
Ethyl 3-methyl-3-phenylglycidate
Ethyl(methylphenyl)glycidate
FEMA No. 2444
Fraeseol
Chemical Function
Fragrance
Viscosity modifier
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
IFRA Transparency
Europe
consumer_product
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
3-METHYL-3-PHENYL GLYCIDIC ACID ETHYL ESTER
Food Category
flavoring
Frequently Asked Questions
Is Ethyl Methylphenylglycidate allowed in the EU?
Ethyl Methylphenylglycidate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Ethyl Methylphenylglycidate do in cosmetics?
Ethyl Methylphenylglycidate functions as: Fragrance (also known as Strawberry Aldehyde / Aldehyde C-16). It is classified as a cosmetic ingredient in our database. CAS number: 77-83-8.
What is the NOAEL for Ethyl Methylphenylglycidate?
The NOAEL (No Observed Adverse Effect Level) for Ethyl Methylphenylglycidate is 50 mg/kg bw/day based on a Chronic study via oral route in rat. A total of 5 study endpoints are available. Source: COSMOS_DB.
Is Ethyl Methylphenylglycidate used outside cosmetics?
Ethyl Methylphenylglycidate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Ethyl Methylphenylglycidate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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