Is Escin safe in cosmetics?
Escin has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Escin
Also known as: Aescin, UNII-RUU8G67GQM
INCI: ESCIN
Escin (CAS 6805-41-0) is a cosmetic cosmetic ingredient functioning as Anti-inflammatory, Skin Conditioning, Antioxidant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 6805-41-0 →
Auto-generated CPSR Part A draft with source citations
Function
Anti-inflammatory, Skin Conditioning, Antioxidant
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
(2S,3S,4S,5R,6R)-6-[[(4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(Z)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid;(2S,3S,4S,5R,6R)-6-[[(4S,6aR,6bS,8R,8aR,9R,10R,14bR)-9-acetyloxy-8-hydroxy-4,8a-bis(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-4-hydroxy-3,5-bis[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy]oxane-2-carboxylic acid
InChIKey
YFESOSRPNPYODN-RSMWSHJLSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No GRAS classification; no OTC monograph status; no standalone CIR final report for isolated escin
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Escin.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
No specific technical function
Expert Verdict
Expert safety assessment and concern-level summary for Escin.
Regulatory Flags
saponin
triterpenoid
anti-cellulite
venotonic
horse-chestnut
no-sccs-opinion
no-cir-review
reach-registered
haemolytic-in-vitro
Known Synonyms
Aescin
UNII-RUU8G67GQM
Chemical Function
Humectant
No specific technical function
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
escin
ChEMBL ID
CHEMBL1159567
Frequently Asked Questions
Is Escin allowed in the EU?
Escin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Escin do in cosmetics?
Escin functions as: Anti-inflammatory, Skin Conditioning, Antioxidant. It is classified as a cosmetic ingredient in our database. CAS number: 6805-41-0.
Is Escin used outside cosmetics?
Escin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Escin compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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ETHOXY-METHOXYMETHYL-PHENOL
Good
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Perfuming
ETHOXYDIGLYCOL ACETATE
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