Is Enoxolone (Glycyrrhetinic Acid) safe in cosmetics?
Enoxolone (Glycyrrhetinic Acid) has a safety rating of "GOOD" in our database. EU status: permitted. US status: restricted.
Good
Active Ingredient
Enoxolone (Glycyrrhetinic Acid)
Also known as: Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-, Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-, Enoxolone, Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-, 8beta-Glycyrrhetinic acid (+15 more)
INCI: GLYCYRRHETINIC ACID
Enoxolone (Glycyrrhetinic Acid) (CAS 471-53-4) is a cosmetic active ingredient functioning as skin-conditioning agent-miscellaneous. EU Regulation 1223/2009 status: permitted, max 2%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 471-53-4 →
Auto-generated CPSR Part A draft with source citations
Function
skin-conditioning agent-miscellaneous
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
EU Max Conc.
2%
US US Status
restricted
US Notes
OTC drug ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Enoxolone (Glycyrrhetinic Acid).
Calculate MoS for your specific formulation with the MoS Calculator.
EPA ToxValDB — Toxicity Values
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >2000 mg/kg | Rat | oral | - | ECHA IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Enoxolone (Glycyrrhetinic Acid).
Known Synonyms
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-
Enoxolone
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-
8beta-Glycyrrhetinic acid
4-10-00-03775
BRN 2229654
EINECS 207-444-6
18-beta-Glycyrrhetic acid
18-beta-Glycyrrhetinic acid
3-beta-Hydroxy-11-oxoolean-12-en-30-oic acid
Enoxolonum
UNII-P540XA09DR
(2S,4aS,6aS,6bR,10S,12aS)-10-hydroxy-2,4a,6a,6b,9,9,12a-heptamethyl-13-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-2-carboxylic acid
18b-Glycyrrhetic acid
18b-Glycyrrhetinic acid
18b-Glycyrrhtinic acid
18beta-glycyrrhetic acid
3-Glycyrrhetinic acid
3-Hydroxy-11-oxoolean-12-en-29-oate
Chemical Function
Softener and conditioner
Regulatory Lists
pharmaceutical
Canada; pharmaceutical
Canada; Personal care; Substances in PCP - Canada (4/2014)
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ENOXOLONE
ChEMBL ID
CHEMBL230006
Max Phase
2
Frequently Asked Questions
Is Enoxolone (Glycyrrhetinic Acid) allowed in the EU?
Enoxolone (Glycyrrhetinic Acid) EU regulatory status: permitted. Maximum allowed concentration: 2%. This is based on EU Regulation 1223/2009 and its amendments.
What does Enoxolone (Glycyrrhetinic Acid) do in cosmetics?
Enoxolone (Glycyrrhetinic Acid) functions as: skin-conditioning agent-miscellaneous. It is classified as a Active Ingredient in our database. CAS number: 471-53-4.
Is Enoxolone (Glycyrrhetinic Acid) used outside cosmetics?
Enoxolone (Glycyrrhetinic Acid) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Enoxolone (Glycyrrhetinic Acid) compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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