What is the NOAEL for Glycyrrhetinic acid?
Glycyrrhetinic acid has 5 NOAEL studies in the database. The lowest reported value is P540XA09DR UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Glycyrrhetinic acid
Also known as: Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-, Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-, Enoxolone, Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-, 8beta-Glycyrrhetinic acid (+15 more)
CAS 471-53-4
Glycyrrhetinic acid (CAS 471-53-4) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Enoxolone (Glycyrrhetinic Acid) →
SOURCE
noael studies public
NOAEL studies
5
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Glycyrrhetinic acid
CAS Number
471-53-4
DTXSID
DTXSID9020669
Molecular Formula
C30H46O4
InChI Key
MPDGHEJMBKOTSU-YKLVYJNSSA-N
Monoisotopic Mass
470.33961
Synonyms
Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3.beta.,20.beta.)-Olean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3beta,20beta)-EnoxoloneOlean-12-en-29-oic acid, 3-hydroxy-11-oxo-, (3β,20β)-8beta-Glycyrrhetinic acid4-10-00-03775BRN 2229654EINECS 207-444-618-beta-Glycyrrhetic acid18-beta-Glycyrrhetinic acid3-beta-Hydroxy-11-oxoolean-12-en-30-oic acidEnoxolonum
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Softener and conditioner
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; Personal care; Substances in PCP - Canada (4/2014) | Government of Canada | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 5 of 5 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| P540XA09DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P540XA09DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P540XA09DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| P540XA09DR | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 0.05 | fraction | Fu | - | Rat | NTP_ICE_adme_parameters |
Showing 5 of 5 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Enoxolone | 207-444-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
2%
Category
active
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
ENOXOLONE
ChEMBL Phase
2
Adverse Events
0
Bioactivity
26
Frequently Asked Questions
What regulatory lists include Glycyrrhetinic acid?
Glycyrrhetinic acid appears on 3 regulatory/inventory lists including pharmaceutical, Canada; pharmaceutical, Canada; Personal care; Substances in PCP - Canada (4/2014). Source: EPA CPDat.
Is Glycyrrhetinic acid used in cosmetics?
Yes, Glycyrrhetinic acid is also indexed as a cosmetic ingredient under the name Enoxolone (Glycyrrhetinic Acid). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Glycyrrhetinic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is Glycyrrhetinic acid used outside industrial chemicals?
Glycyrrhetinic acid also appears in cosmetics, pharmaceutical databases.