NOAEL Studies Cosmetic Ingredient

Disodium Succinate NOAEL Studies

INCI: DISODIUM SUCCINATE

CAS: 150-90-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS DB 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS DB NOAEL 180 mg/kg bw/day rat oral 52 day Reproductive US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
COSMOS DB NOAEL 500 mg/kg bw/day rat oral 51 day Short Term Toxicity US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
ECHA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ECHA NOAEL =100 mg/kg bw/day Rat oral subchronic; 52 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae97e4b0a7c65d1c9fd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24152/7/6/2?documentUUID=67634b04-7449-41e1-97d2-4c86574de0e6; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=clinical biochemistry|urinalysis; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry|urinalysis; STUDY_GROUP=ECHA IUCLID:15834119:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_92dec6e92c70d1b28f5e6dc860299d97
ECHA NOAEL =300 mg/kg bw/day Rat oral subchronic; 52 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eae97e4b0a7c65d1c9fd1; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/24152/7/6/2?documentUUID=67634b04-7449-41e1-97d2-4c86574de0e6; YEAR=2021; ORIGINAL_YEAR=2021; TOXICOLOGICAL_EFFECT=clinical biochemistry; TOXICOLOGICAL_EFFECT_CATEGORY=clinical chemistry; STUDY_GROUP=ECHA IUCLID:15834120:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_f70f5f30f73810aaa16a6208593b2e68
ToxValDB GESTIS DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB GESTIS DNEL DNEL systemic =41.1 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15631653:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_e8a5d19bde5eae224aab6c9dfa0d2cc8
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier V8ZGC8ISR3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H4O4.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V8ZGC8ISR3"}
openFDA substances FDA UNII substance identifier V8ZGC8ISR3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H4O4.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V8ZGC8ISR3"}
openFDA substances FDA UNII substance identifier V8ZGC8ISR3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H4O4.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V8ZGC8ISR3"}
openFDA substances FDA UNII substance identifier V8ZGC8ISR3 UNII - - - chemical {"approval_status":null,"molecular_formula":"C4H4O4.2Na","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"V8ZGC8ISR3"}